This study aimed to investigate the safety and effectiveness of irreversible electroporation ablation for unresectable large liver cancer. Fourteen patients were enrolled: 8 with large hepatocellular carcinoma (tumor diameter: 5.1-11.5 cm) and 6 with medium hepatocellular carcinoma (tumor diameter: 3.0-4.1 cm). All patients received percutaneous irreversible electroporation ablation. Ablation t...

Articles you may be interested in Simultaneous chemical and electrical stimulation on lung cancer cells using a multichannel-dual-electric-field chip Tuning nano electric field to affect restrictive membrane area on localized single cell nano-electroporation Appl. Model study of electroporation effects on the dielectrophoretic response of spheroidal cells Electroporation is being successfully u...

Electroporation-based therapies, such as electrochemotherapy and electrogene therapy, result in the disruption of blood vessel networks in vivo and cause changes in blood flow and vascular permeability. The effects of electroporation on the cytoskeleton of cultured primary endothelial cells and on endothelial monolayer permeability were investigated to elucidate possible mechanisms involved. Hu...

This paper presents the characteristics of potato and apple tissues, with/out electroporation, by Time Domain-Nuclear Magnetic Resonance (TD-NMR). A portable TD-NMR was used to measure proton relaxation time, T2, changes in cells due molecular water mobility tubers,-NMR identify modifications that occurred at cell level involving molecules tubers tissues after electroporation treatment compared...

the effect of external magnetic and electric fields, in the range of electroporation and magnetoporation, on lucifer yellow (ly) fluorescence in the absence of cells is studied. electric-field-induced quenching and magnetic field-induced increase are observed for fluorescence intensity of ly. regard to the fact that the variation of field-induced fluorescence, even in the absence of cells, can ...

Thermal loading effects in flow-through electroporation microfluidic devices have been systematically investigated by using dye-based ratiometric luminescence thermometry. Fluorescence measurements have revealed the crucial role played by both the applied electric field and flow rate on the induced temperature increments at the electroporation sections of the devices. It has been found that Jou...

In many electroporation applications mass transport in biological tissue is of primary concern. This paper presents a theoretical advancement in the field and gives some examples of model use in electroporation applications. The study focuses on post-treatment solute diffusion. We use a dual-porosity approach to describe solute diffusion in electroporated biological tissue. The cellular membran...

To date, there is no effective therapy for hormone-independent prostate cancer. Therefore, as a new strategy for refractory cancer, gene therapy is showing increasing promise. In this study, we attempted to use a nonviral gene transfer system, in vivo electroporation, in prostate cancer cell PC-3 xenografts with the wild-type p53 (wt-p53) gene, as gene therapy for hormone-independent prostate c...

High voltage electric pulses cause electroporation of the cell membrane. Consequently, flow of the molecules across the membrane increases. In our study we investigated possibility to predict the percentage of the electroporated cells in an inhomogeneous electric field on the basis of the experimental results obtained when cells were exposed to a homogeneous electric field. We compared and eval...

BACKGROUND In order to reduce the side-effects of chemotherapy, combined chemotherapy-electroporation (electrochemotherapy) has been suggested. Electroporation, application of appropriate electric pulses to biological cells, can significantly enhance molecular uptake of cells due to formation of transient pores in the cell membrane. It was experimentally demonstrated that the efficiency of elec...