Past work in this laboratory has shown that nuclear particles generated during electrolysis can be registered by CR39 plastic detectors held within the electrolyte solution, suspended in the vapor above the solution, or placed just below the metal cathode that serves as the bottom of the electrolyte compartment of the electrolysis cell. However, not every electrolysis experiment produced nuclea...

Background: T cell immunoglobulin-3 (Tim-3) is identified as a negative regulator of anti-tumor immunity. Recently, Tim-3 expression has been demonstrated in leukemic stem cells (LSCs) of acute myelogenous leukemia (AML), however, the alterations of Tim-3, as well as its marker and prognostic significance has yet to be evaluated in patients with AML. The present study is designed to investigate...

BACKGROUND The purpose of this study was to assess the safety and efficacy of fixed-combination brinzolamide 1%/timolol 0.5% (BRINZ/TIM-FC) compared with concomitant brinzolamide 1% and timolol 0.5% (BRINZ + TIM) in Japanese patients with open-angle glaucoma (primary open-angle, exfoliation, pigmentary) or ocular hypertension. METHODS This randomized, double-masked, multicenter, parallel-grou...

T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein that was originally identified as a marker for murine T helper type 1 cells. TIM-3 was found to negatively regulate murine T cell responses and galectin-9 was described as a binding partner that mediates T cell inhibitory effects of TIM-3. Moreover, it was reported that like PD-1 the classical exhaustion marker, ...

T cell immunoglobulin mucin-3 (Tim-3) has previously been implicated in the immune response and tumor biology. Colorectal carcinoma (CRC) is a malignancy, which is closely associated with inflammation. However, the role of Tim‑3 in the progression of CRC remains to be fully elucidated. The present study aimed to investigate the role of Tim‑3 in the progressive activities of human CRC. A total o...

Abstract We examined polychlorinated dibenzo-p-dioxin, polychlorinated dibenzofuran (PCDD/Fs) and dioxin-like compounds formation during brine electrolysis with pitch used as the binding agent of graphite electrode. Graphite electrode was used in the past as an industrial process of chlorine production. The level of PCDFs was up to 1,800,000pg/L (28,000pg-TEQ/L) in brine electrolysis with pitch...

Three electrolysis cells with built-in ultrasonic transmitters were developed by Energetics Technologies. The ultrasonic transmitters induce cavitation in the electrolyte in the vicinity of the palladium cathode for in-situ cleaning and activation of the cathode surface, generation of dislocations, assistance in loading and excitation of the Pd-D system. The ultrasonically assisted electrolysis...

Ligation of the transmembrane protein T cell Ig and mucin domain (Tim)-1 can costimulate T cell activation. Agonistic Abs to Tim-1 are also capable of inducing T cell activation without additional stimuli. However, little is known about the biochemical mechanisms underlying T cell stimulation or costimulation through Tim-1. We show that a tyrosine in Tim-1 becomes phosphorylated in a lck-depend...

T cell Ig and mucin domain (TIM)-4 is involved in immune regulation. However, the pathological function of TIM-4 has not been understood and remains to be clarified in various disease models. In this study, DBA/1 mice were treated with anti-TIM-4 mAb during the induction or effector phase of collagen-induced arthritis (CIA). Anti-TIM-4 treatment in the induction phase exacerbated the developmen...

BACKGROUND T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown that N-glycosylation affects the binding activity of the Tim-3-Ig fusion protein to its ligand, galectin-9, but the binding properties of non-glycosylated Tim-3 on CD4(+)CD25(+) T ce...