Image-based surrogates became increasingly important in controlled clinical trials developing novel drugs and medical devices. However, there is as yet no structured way to collect digital imaging and communications in medicine (DICOM) objects in electronic data capture systems (EDCS), i.e., the trial database systems. Recently, van Herk obtained a tight connection of electronic case report for...

The fact that many known and suspected endocrine disrupting chemicals (EDCs) are being found at environmentally significant concentrations in the effluent of wastewater treatment plants (WWTPs) is receiving increasing attention in public and regulatory arenas. The public is concerned about the safety of consuming trace amounts of EDCs in drinking water, though the only confirmed negative effect...

The estrogen receptor protein (ER) can bind a vast number of organic pollutants widely spread in the environment and collectively known as Endocrine Disrupting Chemicals, EDCs. Its broad selectivity makes it an ideal bio-recognition element for the detection of EDCs. Here we describe the strategy and rationale for the design of ER based biosensors and assays that generate a signal in the presen...

Introduction The association between the exposure and bioaccumulation of endocrine disruptor chemicals (EDCs) and their adverse effects on human and wild life populations has raised concern worldwide. Due to the detrimental effects of environmental exposure to EDCs, there is an obvious need to develop a relevant bioassay, which can both detect these chemicals, as well as provide a relevant esti...

Exposure to endocrine disrupting chemicals (EDCs) is a widespread phenomenon in nature. Although the mechanisms of action of EDCs are actively studied, the consequences of endocrine disruption (ED) at the population level and the adaptations evolved to cope with chronic EDC exposure have been overlooked. Birds probably represent the animal taxon most successfully adapted to synanthropic life. H...

This commentary addresses the article by Berman, et al. on reproductive health trends in Israel potentially related to endocrine disrupting chemicals (EDCs) and on associated health policy decisions in Israel to prevent long-term effects from exposure to EDCs. There are intensive, ongoing research efforts in the US that will provide additional guidance on this issue in the future. The commentar...

CTSAs have brought about a push to find better EDC systems, which facilitate translational research. Based on the data management needs of a specific clinical/translational research lab, concept mapping was used to create a framework to evaluate EDCs. After refinement based on a spiral model, including consultations with the UW CTSA and a survey of other CTSAs, the tool was used to characterize...

There has been much concern whether Endocrine Disrupting Chemicals (EDCs) play a role in the recent increase in the incidence of certain hormone sensitive cancer forms. There is at present, however, no proven causal link between exposure to EDCs and human cancer in any of the organs supposed to be at highest risk, i.e., the testis, breast, prostate, and endometrium. This may be due to a real ab...

Evolving an existing software system is fundamentally different from developing one from scratch. Consequently, tools to support evolution must go beyond traditional development tools. This paper describes the Esprit de Corps Suite (EDCS) of software evolution tools. EDCS supports the Mission Oriented Architectural Legacy Evolution (MORALE) software reengineering process. The paper briefly desc...