Background The median effective dose of ropivacaine required for producing an costoclavicular block has not yet been determined. authors conducted this dose-finding study with the objective determining 0.5% to produce a successful surgical anesthesia in 50% patients (ED50) as well calculated blockade 95% (ED95). Methods This single-armed prospective was on 40 American Society Anesthesiologists ...

two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4h-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (ptz). diazepam (sigma) was considered as a positive control drug with anticonvulsant effect [ed50 = 1.2 (0.5-1.9) mg/kg]. amongs...

Study selection and analysis: Double blind, randomised controlled trials of people with schizophrenia or schizoaffective disorder comparing two or more doses of typical or atypical antipsychotics were eligible. Dose response curves were plotted and the median effective dose, defined as 50% of the maximum response (ED50), and the near maximal effective dose range (ED85 to ED95) was established f...

Results: On the hot plate model ED50 value was per body weight 0.34 (0.18 0.63) mg/kg of the pyrodazol /i.g, 1.00 (0.59 1.70) mg/kg/of the ketorolac/ i. g. in 90 minutes post administration. On the hot plate model in 0.3 1.3 mg/kg/doses i.m the pirodazol is similar to morphine hydrochloride in dose 2.5 mg/kg i.m. On the tail-flick model ED50 values of the pyrodazol and ketorolac are 1.9 (1.12 3...

background combining different analgesic drugs for improvement of drug efficacy is a recommended strategy intended to achieve the optimal therapeutic effects. objectives the purpose of the present study was to assess the nature of the interaction between ascorbic acid and two analgesic drugs, morphine and tramadol. materials and methods the analgesic activity was assessed by the acetic acid wri...

Pelargonic acid is a non-selective post-emergence contact bio-herbicide which registered both for cropping and non-cropping uses in several countries. Dose–response curves on the efficacy of pelargonic against common weeds Mediterranean areas are not available. summer winter annual were evaluated two field experiments (winter exp. 2019 2020) central Italy. was applied at five doses (1.4, 2.7, 5...

11C-LY2795050 is a novel k-selective antagonist PET tracer. The in vitro binding affinities (Ki) of LY2795050 at the k-opioid (KOR) and m-opioid (MOR) receptors are 0.72 and 25.8 nM, respectively. Thus, the in vitro KOR/MOR binding selectivity is about 36:1. Our goal in this study was to determine the in vivo selectivity of this new KOR antagonist tracer in the monkey. Methods: To estimate the ...