Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main source(s): Deutsche Stiftung für Herzforschung research grant Background Electromagnetic interference (EMI) poses a risk to patients with cardiac implantable devices (CIEDs) and can result in device malfunction including pacing inhibition or inappropriate shock therapy. Such EMI sources are ubiquitous the mod...

Chimeric antigen receptors (CARs) provide a promising new approach for generating T cell populations for the adoptive immunotherapy of cancer. CAR T cell (CART) therapies demonstrate activity against leukemias in preclinical and clinical studies, but CART targeting solid tumors have been less impressive. We hypothesized that the observed differences could be due to a more hostile microenvironme...

The integration of hardware and software components into today’s vehicles from a variety of suppliers is a complex process and becomes more and more challenging. The amount of code and data as well as the number of interconnections increases rapidly and pushes the complexity of the on-board electronic systems and the involved infrastructure to new limits. This stands in contrast with the consta...

Economists have long advocated for electricity pricing that accurately reflects time-varying production costs. In particular, real-time pricing (RTP) would improve the efficiency of electricity consumption and investment and would lessen the potential harm from market power. Conventional wisdom has claimed that RTP has an additional benefit, namely, reduced emissions from reduced peak demand. W...

14 As happens on many college campuses at the beginning of an academic year, thousands of students move into campus housing on Indiana University’s Bloomington and Indianapolis campuses within a threeday period. More than 96 percent arrive with at least one personal computer (and possibly also a PDA, cell phone, and gaming system), and most expect to connect to the campus network within a few h...

OBJECTIVES AND METHODS Using a randomized, crossover, counterbalanced approach, cyclists (N = 20, overnight fasted state) engaged in the four 75-km time trials (2-week washout) while ingesting two types of bananas with similar carbohydrate (CHO) but different phenolic content (Cavendish, CAV; mini-yellow, MIY, 63% higher polyphenols), a 6% sugar beverage (SUG), and water only (WAT). CHO intake ...

Background: Juvenile idiopathic arthritis (JIA) was thought to be the most common inflammatory in children (Shih et al. , 2019). However an aggressive, erosive of little-known immunologic mechanism occurs 20 times more frequently with Down’s syndrome (Foley Objectives: This study undertaken characterize immune cell responses and synovial fibroblast invasiveness syndrome-associated (DA). Methods...

The American electric power industry is undergoing dramatic changes in the way it is structured and regulated. As of June of 1998, state utility regulators, state legislatures or both in 17 states had made the decision to implement retail competition within 5 years or less. Competition in electricity markets and associated new opportunities for expanded interregional electricity trading could r...

It recently came to the authors' attention that the tubulin loading control panels shown in Figs. 2 G and S2 F were incorrect as a result of errors introduced during figure preparation. The authors apologize for these mistakes. The conclusions of the experiments shown in these figures are not affected. A corrected version of Fig. 2 is shown below. The LC3 panel originally published in the top p...

Cancer cells, unlike normal cells, show selective dependency on certain nutrient substrates. These cells exhibit an addiction to glucose or glutamine, and a lack of flexibility in using a full spectrum of nutrient substrates. This dependency varies widely among different cancer cell types and depends on specific mutations in oncogenes and tumor suppressors, the cellular context in which these m...