AIM To establish whether infection with Epstein-Barr virus (EBV) contributed to the development of coronary artery lesions in a six year old child with an aneurysm and stenoses of the coronary arteries and suspected Kawasaki disease. METHODS Postmortem paraffin wax sections of the coronary artery and myocardium were examined by in situ hybridisation for expression of EBER-1 (EBV-encoded RNA-1...

The clonal composition of EBV-infected cells was examined in three cases of EBV-associated hemophagocytic syndrome by analysis of the heterogeneity of terminal repetitive sequences in the EBV genome, indicating monoclonal expansion of EBV-infected cells in all cases. Involvement of T lymphoid cells was determined by in situ hybridization using 35S-labeled RNA probes specific for the small EBV-e...

We report the case of a 72-year-old man with 2 simultaneous gastric carcinomas. The larger, ulcerated mass in the antrum was a conventional infiltrating intestinal-type adenocarcinoma. The associated antral-type mucosa showed moderate chronic gastritis, foci with complete and incomplete intestinal metaplasia, and mild to moderate Helicobacter pylori infection. The second, smaller tumor was foun...

The Epstein-Barr virus (EBV) infection is an endemic disease, over 90% of the population being exposed to it by adulthood. EBV is implicated in the etiology of a significant number of neoplasms, which acquire particular features in terms of course and prognosis. Incidence rates are much higher in children. To establish the link between EBV and neoplasms, EBER (Epstein-Barr virus non-encoded RNA...

ROSLYN M. LONDON,2 SAMMY L. EBER,1,2 SANDHYA S. VISWESWARIAH,4 WILLIAM J. KRAUSE,3 AND LEONARD R. FORTE1,2 1Harry S. Truman Memorial Veterans Hospital and Departments of 2Pharmacology, and 3Pathology and Anatomical Sciences, School of Medicine, Missouri University, Columbia, Missouri 65212; and 4Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalo...

INTRODUCTION Nasopharyngeal carcinoma (NPC) is a common cancer in the North-East region of India. Though the role of environmental contributors of NPC in the North-Eastern part of India is firmly established, EBV as an etiological agent in the region remains unexplored. MATERIAL AND METHODS Fifty-one patients, who presented at the department of ENT, NEIGRIHMS and were confirmed as NPC upon hi...