OBJECTIVES Pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancers (BTC) are often diagnosed late and at an advanced stage. Population-based screening programmes do not exist and diagnosis is primarily dependent on symptom recognition. Recently symptom-based cancer decision support tools (CDSTs) have been introduced into primary care practices throughout the UK to support general prac...

OBJECTIVE This study tested whether the quality of the patient-rated working alliance, measured early in treatment, predicted subsequent symptom reduction in chronically depressed patients. Secondarily, the study assessed whether the relationship between early alliance and response to treatment differed between patients receiving cognitive behavioral analysis system of psychotherapy (CBASP) vs....

OBJECTIVE To determine the frequency of early computed tomographic (CT) findings of ischemia and their relationship to symptom duration and neurologic dysfunction within 3 hours of ischemic stroke. METHODS The CT scans of 39 acute stroke patients were evaluated for signs of early ischemic change within 3 hours of symptom onset and without knowledge of the patient's neurologic deficit or resul...

OBJECTIVE Effective treatment can only be given during the early stages of RA if patients are seen early. However, many patients delay for prolonged periods before seeking medical advice. This study explores factors influencing the decision to seek medical advice in RA patients. METHODS In-depth, semi-structured interviews were carried out with 24 patients. Purposive sampling ensured a cross-...

OBJECTIVE To examine ADHD symptom persistence and factors associated with elevated symptom counts in a diverse, longitudinal community-based sample. METHOD Parents reported demographics and completed a diagnostic interview repeatedly over a 6-year period. At Time 1, 481 interviews were completed about children (5-13 years); all participants were invited to four annual follow-up interviews, an...

FDA has approved Azstarys (KemPharm), the first ADHD medication to combine two medications, 70% serdexmethylphenidate (SDX) and 30% immediate-release dexmethylphenidate (d-MPH), in a once-daily capsule for treatment of patients ages 6 years older. Because d-MPH is fully absorbed within about 2 hours, while SDX slowly over several drug provides both early onset action longer duration therapy.Dos...