Age of puberty onset is considered to be of general public health relevance. A downward secular trend in age of puberty onset has now been repeatedly reported in both developed (1) and developing countries (2). Early puberty onset has been suggested to be a risk factor for a series of diseases in later life, including hormone-related cancer, type 2 diabetes mellitus, metabolic syndrome, cardiov...

PURPOSE Long-acting gonadotropin-releasing hormone agonists (GnRHa) are commonly used to treat central precocious puberty (CPP) in Korea. Although rare, there have been reports on the characteristic of adverse reactions of GnRHa in CPP among the Korean population. This study was intended to report on our clinical experience regarding significant adverse reactions to long-acting GnRHa in CPP and...

CONTEXT The timing of the onset of puberty is considered to approximate a normal distribution. However, because many more girls present with early than late puberty, we hypothesized that the distribution of the timing of the onset of puberty in girls might have changed. OBJECTIVE/SUBJECTS: The objective of the study was to examine the distribution of the timing of the onset of puberty in normal...

Early puberty affects in particular males in commercially farmed European fin-fish species, resulting in reduced growth and feed conversion, and the potential problem of unwanted genetic impacts on wild stocks. Controlling photoperiod can be an effective way to prevent early sexual maturation. Combining national and international resources provided the means to embark on a research program to i...

Early puberty in 28 children (23 girls, five boys) treated for acute lymphoblastic leukaemia (ALL) at a mean age of 4.0 years (range 1.4-7.8) is described. All but one had received prophylactic cranial irradiation (1800-2400 cGy) and three children had received additional cranial or craniospinal irradiation as treatment for relapse of their leukaemia. Mean age for the onset of puberty was 8.8 (...

Disorders of pubertal timing are common and challenging problems for pediatric endocrinologists. Early or late puberty can have immediate effects on a child's psychosocial well-being and may have long-term effects on adult stature. Much is known about the regulation of the hypothalamic-pituitary-gonadal axis, but the triggers of pubertal onset in the general population remain elusive. This arti...

Precocious puberty (PP) is defined as the development of pubertal changes before the accepted age of its onset. In girls the lower limit of puberty is set at8 year.[1] With PP early secondary sexual changes appear. By definition it is presence of signs at Tanner 2 stage. It starts at 8 year of age and continues till 15 year of age. The signs include elevation of breast and its papilla with the ...

OBJECTIVE Precocious puberty leads to discrepancies between physical and chronological age. The aim of the present study was to evaluate behavioral patterns and social competences in 34 girls with idiopathic precocious puberty. METHODS Height, body weight, and BMI were determined, and pubertal development was assessed. The Korean-child behavior checklist (K-CBCL) was completed by parents. R...

BACKGROUND Steroidogenic factor 1 (SF-1, NR5A1) is a key transcriptional regulator of many genes involved in the hypothalamic-pituitary-gonadal axis and mutations in NR5A1 can result in 46,XY disorders of sex development (DSD). Patients with this condition typically present with ambiguous genitalia, partial gonadal dysgenesis, and absent/rudimentary Müllerian structures. In these cases, testost...

In adult animals, the consequences of stress are often severe and long lasting. Repeated subjugation in adult male golden hamsters inhibits aggression and increases submissive and avoidant behaviours. By contrast, subjugation during puberty enhances offensive aggression. The goals of this study were to characterize behavioural and neuroendocrine responses of naïve and repeatedly subjugated juve...