The significance of junctional feet (Franzini-Armstrong 1971) for excitation-contraction (E-C) coupling is suggested by their location in the gap separating the T-system from the sarcoplasmic reticulum (SR). Until now, however, no specific treatment for selectively disrupting junctional feet has been known and the direct evidence relating the presence of feet to the transfer of signals across t...

We have labeled every transition in the model with a score. Transitions to state M indicate letter-to-letter correspondences, so they are labeled with s(xi, yj) corresponding to the substitution score for replacing xi with yj. We know which i and j to use, based on the current sum of +1’s for x and y thus far. We label every transition from M to a gap state (I or J) with the gap initiation pena...

Abstract: Electrical sensitivity of a boron nitride nanotube (BNNT) was examined toward pyrrole (C5H6N) molecule by using density functional theory (DFT) calculations at the B3LYP/6-31G (d) level, and it was found that the adsorption energy (Ead) of pyrrole on the pristine nanotubes is a bout -16.37kcal/mol. But when nanotube have been doped with Si and Al atom...

Abstract: Electrical sensitivity of a beryllium oxide nanotube (BeONT) was examined toward (C5H5N) molecule by using density functional theory (DFT) calculations at the B3LYP/6-31(d) level, and it was found that the adsorption energy (Ead) of pyridine on the pristine nanotubes is   a bout -73.29kcal/mol. But when nanotubes has been doped with S and P atomes , t...

We present a model of X-ray emission from rotation-powered pulsars, which in general consist of one nonthermal component, two hard thermal components, and one soft thermal component. The nonthermal X-rays come from synchrotron radiation of eB pairs created in the strong magnetic Ðeld near the neutron star surface by curvature photons emitted by charged particles on their way from the outer gap ...

Gap junctions provide a low-resistance pathway for cardiac electric propagation. The role of GJ regulation in arrhythmia is unclear, partly because of limited availability of pharmacological tools. Recently, we showed that a peptide called "RXP-E" binds to the carboxyl terminal of connexin43 and prevents chemically induced uncoupling in connexin43-expressing N2a cells. Here, pull-down experimen...

Gap junctions provide a low-resistance pathway for cardiac electric propagation. The role of GJ regulation in arrhythmia is unclear, partly because of limited availability of pharmacological tools. Recently, we showed that a peptide called “RXP-E” binds to the carboxyl terminal of connexin43 and prevents chemically induced uncoupling in connexin43-expressing N2a cells. Here, pull-down experimen...

A quantum system (with Hilbert space H1) entangled with its environment (with Hilbert space H2) is usually not attributed a wave function but only a reduced density matrix ρ1. Nevertheless, there is a precise way of attributing to it a random wave function ψ1, called its conditional wave function, whose probability distribution μ1 depends on the entangled wave function ψ ∈ H1 ⊗H2 in the Hilbert...

Tunable photonic crystals PCs have attracted much attention in the past decade because of their various applications, such as ultrafast optical filters and optical waveguides with add–drop functionalities. One way of achieving tunability is to make use of ferroelectric materials since the refractive index of ferroelectric materials can be electrically tuned through the electro-optic effect. In ...