Recessive dystrophic epidermolysis bullosa (RDEB) manifests with blistering and erosions of the skin mucous membranes due to mutations in COL7A1. The repetitive wounding healing processes lead extensive cutaneous scarring. scarring is driven by inflammatory processes, particularly TGF-b signaling pathways, resulting deposition extracellular matrix, especially collagen. There currently no effect...

A 10-year-old female patient, being treated for dystrophic bullous epidermolysis in a Pediatric Hospital, was referred to our Dermoscopy Ambulatory because of a newly observed mole in the submandibular area. Clinically, the lesion presented as an irregular double-colored macule of about 2 cm in diameter, with irregular borders, suspicious of malignancy. Dermoscopy showed a multicomponent patter...

Epidermolysis bullosa (EB) is a spectrum of conditions characterized by mechanical fragility and blistering the skin. Individuals suffering from EB display wide range symptoms based on affected proteins in different organs tissues body, including craniofacial complex oral cavity. In this case-report, 22-year-old girl with Dominant Dystrophic Bullosa presented. She suffered no other medical comp...

Epidermolysis bullosa comprises a group of phenotypically different genodermatosis, hereditary or acquired, characterized by skin fragility and subsequent formation of blisters in response to mechanical trauma, and which may also affect mucous membranes. This study aimed to analyze the relation between the nutritional, hematologic, infectious characteristics and the type of epidermolysis bullos...

Epidermolysis bullosa (EB) is a group of inherited blistering skin diseases that vary widely in their pathogenesis and severity. There are three main categories of EB: simplex, junctional, and dystrophic. This classification is based on the level of tissue separation within the basement membrane zone and this is attributed to abnormalities of individual or several anchoring proteins that form t...