Few previous studies have discussed the changes in serotonin receptor activity in the small intestine of diabetic animals. Therefore, we examined serotonin content in duodenal tissue and dose-dependent effects of serotonin agonists and antagonists on the motor activity of ex vivo vascularly perfused duodenum of streptozotocin (STZ)-diabetic rats. Serotonin content was significantly increased in...

I . Using shccp fitted with re-entrant cannulas in the proximal duodenum, and which were given a ration containing long straw, a series of three experiments was conducted in which the flow of digcsta to the duodenum was measured and sampled continuously for 3 d. Therc appeared to be no consistent effect of this procedure on total flow of digesta to the duodenum from day to day, indicating that ...

The purpose of this prospective study was to establish the ultrasonographic characteristics of the dimension of the right pancreatic lobe with that of the associated anatomic landmarks in healthy dogs. Ultrasonographic examinations were performed on 25 dogs. The thickness of the right pancreatic lobe was compared with that of mural thickness of duodenum, diameter of duodenum, pancreatic duct, a...

The myenteric plexus of the gastrointestinal tract was investigated in the obese diabetic mouse, an animal model of human type 2 diabetes. Sections were immunostained by the avidin-biotin complex method, using a general nerve marker, protein gene product 9.5 (PGP 9.5), as well as antibodies to several important neurotransmitters. Computerized image analysis was used for quantification. When dia...

Primary adenocarcinoma of the duodenum is a rare condition representing around 0.5% of all gastrointestinal tract cancers. 1-5 Adenocarcinomas are the most common histological type of malignant neoplasms of the duodenum accounting for 50% of the cases, followed by carcinoid, leiomyosarcomas and lymphomas. 4,6-8 Adenocarcinoma of the duodenum usually occurs between the sixth and seventh decades,...

BACKGROUND Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of the gastrointestinal tract. The biological appearance of these tumors reaches from small lesions with benign appearance to aggressive sarcomas. Only 3-5% of GISTs are localized in the duodenum. There is a controversy, if duodenal GISTs should be treated by a duodenopancreatectomy or by a limited resect...

Gastrointestinal stromal tumors (GISTs) of the duodenum are relatively rare and difficult to diagnose in early stage because it lacks pathognomonic symptoms. Here, we report a case of multiple GISTs involving the third and fourth portions of the duodenum and proximal jejunum, which were revealed in an emergent laparotomy. A 40-year-old, previously healthy man was referred to the Emergency Depar...

BACKGROUND Superior mesenteric artery (SMA) syndrome occurs when the third portion of duodenum becomes tightly compressed between the SMA and the abdominal aorta (AA). Several causes of the SMA syndrome have been postulated such as marked weight loss, external compression of the abdomen, anatomic variation, and surgical alterations of anatomy. This is an autopsy case of a subject with atypical ...

Inflammatory myofibroblastic tumors (IMTs) are rare soft-tissue tumors that can occur at virtually any anatomical site. We report the case of a 58-year-old male with an IMT of the fourth part of the duodenum who presented with signs and symptoms of high intestinal obstruction and bilious vomiting. The patient underwent a surgical resection of the fourth part of the duodenum with end-to-end duod...