A 66-year-old woman presented with a nonhealing duodenal ulcer after undergoing Helicobacter pylori eradication therapy for 1 week and proton pump inhibitor treatment for 4 months. Repeat endoscopy showed the duodenal ulcer with a whitishmucous coating and somewhitish discharge over the bulb. The mucous coating retracted upward with breathing (●" Fig.1). Abdominal sonography revealed gallstones...

Introduction: Peptic ulcer disease is still the major cause of gastro-intestinal perforation despite major improvements in both diagnostic and therapeutic strategies. While the diagnosis of a perforated ulcer is straightforward in typical cases, its clinical onset may be subtle because of co-morbidites and/or concurrent therapies. Case presentation: We report a case of a 53-year-old Caucasian m...

In elective surgery of duodenal ulcers (DU), postoperative mortality reaches 4–6%, with perforation the ulcer – 5–8%, bleeding 20–30%. At same time, leading cause is failure stump, which occurs in 0.4–4.4% patients, significantly increases gastric cancer due to “difficult” ulcers. The authors have developed improved methods and techniques that ensure safety surgical intervention case DU facilit...

INTRODUCTION Although the surgical treatment of patients with perforated duodenal ulcer is the method of choice, the introduction of effective pharmacotherapy has changed the surgical strategy. Nowadays less extensive procedures are chosen more frequently. The introduction of laparoscopic procedures had a significant impact on treatment results. AIM To present our experience in the treatment ...

BACKGROUND Peptic ulcers were believed to be caused by stress, dietary factors, and gastric acid, but the link between H. pylori and peptic ulcers was identified in 1983. To see the frequency of Helicobacter pylori infection in patients with perforated duodenal ulcer and advise eradication therapy in these patients. This cross sectional study was conducted in Surgical Unit Hayatabad Medical Com...

The ideal treatment for the perforation of duodenal ulcer has not yet been established. Accepted methods vary from simple closure to immediate definitive surgery. Simple closure is the general standard procedure against which other methods are evaluated. It is simple, safe and effective for the treatment of emergency problem but provides no protection on long term basis. Several studies have sh...

PROBABLY the first real attempt to ascertain if any casual relationship existed between peptic ulcer and renal disease was contained in a survey of post mortem records by Perry and Shaw (1893). They found that some form of kidney disease was present in seven per cent of deaths and as their cases of duodenal ulcer numbered 70, they reasoned that seven per cent, or five cases, might have been exp...

The ingestion of non-steroidal anti-inflammatory drugs (NSAID) in 272 patients with bleeding or perforated peptic ulcer was compared with 272 age/sex matched controls. A significantly higher proportion of patients with gastric ulcers had received NSAID than those with duodenal ulcers. Twelve of 90 (13%) patients admitted with bleeding duodenal ulcers had received NSAID compared with 11 of 26 (4...

Serum pepsinogen, alpha 1-antitrypsin (alpha 1-AT) and blood groups were studied as genetic markers in 32 patients with endoscopically proven duodenal ulcer and 44 control subjects with no family history of ulcer disease. Serum pepsinogen was determined by the modified method of Edward et al, alpha 1-AT by single radial immunodiffusion (RID) and phenotyping was carried out by isoelectric focusi...