CONTEXT Drug administration in the hospital setting is the last barrier before a possible error reaches the patient. OBJECTIVES We aimed to analyze the prevalence and nature of administration error rate detected by the observation method. DATA SOURCES Embase, MEDLINE, Cochrane Library from 1966 to December 2011 and reference lists of included studies. STUDY SELECTION Observational studies...

1. Aneni EC, Roberson LL, Maziak W, Agatston AS, Feldman T, et al. (2014) A Systematic Review of Internet-Based Worksite Wellness Approaches for Cardiovascular Disease Risk Management: Outcomes, Challenges & Opportunities. PLoS ONE 9(1): e83594. doi:10.1371/journal.pone.0083594 Citation: The PLOS ONE Staff (2014) Correction: A Systematic Review of InternetBased Worksite Wellness Approaches for ...

OBJECTIVE To develop and test a utilization review screening tool for use in European hospitals. SETTING In 1993 a group of researchers financed by a European Union grant reviewed the use of utilization review in Europe. They quickly noticed a lack of specifically designed instruments able to take into account the health care and cultural differences across Europe, and available for use in di...

Following a review of the clinical trials of reboxetine, a new nonadrenegic reuptake inhibitor antidepressant, this paper presents a heuristic theoretical framework to better understand selective antidepressant action. For over three decades, the dominant views of antidepressant action have seen these agents active across all constitutional types and regardless of social setting. An increasing ...

Scheduling product batches in pipelines is a very complex task with many constraints to be considered. Several papers have been published on the subject during the last decade. Most of them are based on large-size MILP discrete time scheduling models whose computational efficiency greatly diminishes for rather long time horizons. By introducing an MILP continuous representation in both time and...

W e consider multimachine scheduling problems with earliness and tardiness costs. We first analyze problems in which the cost of a job is given by a general nondecreasing, convex function F of the absolute deviation of its completion time from a (common) unrestrictive duedate, and the objective is to minimize the sum of the costs incurred for all N jobs. (A special case to which considerable at...

INTRODUCTION Basal cell carcinoma (BCC) is the most common form of skin cancer; however, few data are available relating to patients' perspectives and experiences of this disease. This study explored the spectrum of BCC symptoms and their impact by disease stage to determine how BCC affects the overall health-related quality of life (HRQL) of patients. METHODS This study comprised a cross-sec...

OBJECTIVE To update previous systematic review of predictive models for 28-day or 30-day unplanned hospital readmissions. DESIGN Systematic review. SETTING/DATA SOURCE CINAHL, Embase, MEDLINE from 2011 to 2015. PARTICIPANTS All studies of 28-day and 30-day readmission predictive model. OUTCOME MEASURES Characteristics of the included studies, performance of the identified predictive mod...

Choriocarcinoma is an extremely rare pathology among breast malignancies. It is introduced by two distinct terms in the literatures: breast cancer with choriocarcinomatous features and metastatic choriocarcinoma to the breast. In this case report, the history, physical examination, laboratory findings, imaging studies, and pathological findings of breast choriocarcinoma in a 41-year-old woman a...

Most of the pheochromocytomas (PCCs) are benign neoplasms, but when they are malignant, they can be difficult to treat. Despite advances in diagnosis and imaging, it remains an untreatable tumor, when metastases develop. A deeper understanding of the alteration of the specific molecular pathways causing malignant PCCs might hopefully lead in the future to the development of multiple molecular-t...