The utilization of mathematical modeling and simulation in drug development encompasses multiple mathematical techniques and the location of a drug candidate in the development pipeline. Historically speaking they have been used to analyze experimental data (i.e., Hill equation) and clarify the involved physical and chemical processes (i.e., Fick laws and drug molecule diffusion). In recent yea...

the aim of present study was to prepare gelatin nanoparticle for drug and gene delivery applications. these nanoparticles were prepared by two-step desolvation method. the body distribution of colloidal drug delivery systems was mainly influenced by two physicochemical properties namely particle size and surface characteristics. the influence of several factors on the fabrication process includ...

background: opioid drugs are the most effective drugs for the treatment of moderate to severe pain. rates of opioid use are influenced by a variety of factors. the aim of this study was to determine the pattern of use of parenteral opioid drugs in hospitalized patients in a referral teaching hospital. methods: in a retrospective study, required data were extracted from medical records of adult ...

drug utilization evaluation (due) studies facilitate assessing the appropriateness and rational use of medications.the goal of the present study was to evaluate amphotericin b usage in neutropenic patients. a prospective due study was performed in hematology-oncology and stem cell transplantation wards at taleghani hospital for one-year. national comprehensive cancer network, clinical practice ...

© 2003 Canadian Medical Association or its licensors The marked increase in spending on drugs 1 has led payers such as provincial governments to restrict funding for many drugs to specific clinical indications that are thought to be cost-effective. Some have argued that this unreasonably deprives patients of access to beneficial drugs. In this article we argue for a new approach to drug evaluat...

Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the developmental, testing, and clinical evaluatio...

Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the developmental, testing, and clinical evaluatio...