ABSTRACT Osteosarcoma represents one of the most devastating cancers due to its high metastatic potency and fatality. is insensitive traditional chemotherapy. Identification a small molecule that blocks osteosarcoma progression has been challenge in drug development. Phillygenin, plant-derived tetrahydrofurofuran lignin, shown suppress cancer cell growth inflammatory response. However, how phil...

Although genes have specific phenotypic consequences in a given species, this functional relationship can clearly change during the course of evolution. Many cases of evolutionary dissociations between homologous genes and homologous morphological features are now known. These dissociations have interesting and important implications for understanding the genetic basis for evolutionary change i...

Symmetric homology of a unital algebra A over a commutative ground ring k has been defined using derived functors and the symmetric bar construction of Fiedorowicz, in an analogous way as cyclic, dihedral or quaternionic homology has been defined. In this paper, it is found that the HS∗(A) admits Dyer-Lashoff homology operations, and indeed, there is a Pontryagin product structure making HS∗(A)...

This text is a preliminary version of material used for a course at the University of Copenhagen, part of ”Workshop and Masterclass on Homological stability” August 26-30, 2013. This lecture concerns the method developped, in collaboration with Aurélien Djament, in [DV10] and used in [Dja12] and [DVa] to compute the stable homology of a family of groups with coefficients given by a polynomial f...

The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...

This text is a preliminary version of material used for a course at the University of Copenhagen, part of ”Workshop and Masterclass on Homological stability” August 26-30, 2013. This lecture concerns the method developped, in collaboration with Aurélien Djament, in [DV10] and used in [Dja12] and [DVa] to compute the stable homology of a family of groups with coefficients given by a polynomial f...

A homology stratification is a filtered space with local homology groups constant on strata. Despite being used by Goresky and MacPherson [3] in their proof of topological invariance of intersection homology, homology stratifications do not appear to have been studied in any detail and their properties remain obscure. Here we use them to present a simplified version of the Goresky–MacPherson pr...

We compute the equivariant $KO$-homology of classifying space for proper actions $\textrm{SL}_3(\mathbb{Z})$ and $\textrm{GL}_3(\mathbb{Z})$. also Bredon homology $K$-homology spaces $\textrm{PSL}_2(\mathbb{Z}[\frac{1}{p}])$ $\textrm{SL}_2(\mathbb{Z}[\frac{1}{p}])$ each prime $p$. Finally, we prove Unstable Gromov-Lawson-Rosenberg Conjecture a large class groups whose maximal finite subgroups a...