Antibiotic resistance is an increasing global threat involving many actors, including the general public. We present findings from a content analysis of the coverage of antibiotic resistance in the Swedish print media with respect to the risk communication factors cause, magnitude and countermeasures. The most commonly reported cause of development and spread of resistance was unnecessary presc...

The worldwide epidemic of antibiotic resistance is in danger of ending the golden age of antibiotic therapy. Resistance impacts on all areas of medicine, and is making successful empirical therapy much more difficult to achieve. Antibiotic choices are often severely restricted, and the pipeline of new antibiotics is almost dry. Resistance cannot be prevented, but its development and spread can ...

the conjugative transfer ot genetic information tor antibiotic resistance between bacteria. Durng a hospital epidemic, a majority of Salmonella tvphimurium isolates were sensitive to all antibacterial drugs; but approximately 3 percent were resistant to three unrelated ones, and that multiple resistar.ce was transmrssible, in mixed broth culture, to Shigella sonnei. [The SC/ 5 indicates that th...

BACKGROUND Moxifloxacin is a quinolone antimicrobial that has potent activity against Mycobacterium tuberculosis. To optimize moxifloxacin dose and dose regimen, pharmacodynamic antibiotic-exposure targets associated with maximal microbial kill and complete suppression of drug resistance in M. tuberculosis must be identified. METHODS We used a novel in vitro pharmacodynamic infection model of...

Antibiotic resistance (ABR) is a very serious public health issue. Antibiotics have been “miracle” drugs during many years, but their activity has been reduced sharply by many mechanisms of resistance. New mechanisms make the strains of Gram‐negative bacteria resistant to the 3rd generation cephalosporins, and carbapenems. It is very urgent to act to slow down this phenomenon by global and inte...

The unrestricted use of antibiotics has resulted in rapid acquisition of antibiotic resistance (AR) and spread of multidrug-resistant (MDR) bacterial pathogens. With the advent of next-generation sequencing technologies and their application in understanding MDR pathogen dynamics, it has become imperative to unify AR gene data resources for easy accessibility for researchers. However, due to th...

Conventionally, in Escherichia coli, phylogenetic groups A and B1 are associated with commensal strains while B2 and D are associated with extraintestinal strains. The aim of this study was to evaluate diarrheagenic (DEC) and commensal E. coli phylogeny and its association with antibiotic resistance and clinical characteristics of the diarrheal episode. Phylogenetic groups and antibiotic resist...

The response of Mycobacterium tuberculosis to six anti-microbial agents was determined by microarray analysis in an attempt to define mechanisms of innate resistance in M. tuberculosis. The gene expression profiles of M. tuberculosis after treatment at the minimal inhibitory concentration (MIC) for 4 h with isoniazid, isoxyl, tetrahydrolipstatin, SRI#221, SR1#967 and SR1#9190 were compared to u...

Antimicrobial drug resistance can hinder gonorrhea prevention and control efforts. In this study, we analyzed historical ciprofloxacin resistance data and gonorrhea incidence data to examine the possible effect of antimicrobial drug resistance on gonorrhea incidence at the population level. We analyzed data from the Gonococcal Isolate Surveillance Project and city-level gonorrhea incidence rate...

Recent evidence has shown that antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are ubiquitous in natural environments, including sites considered pristine. To understand the origin of ARGs and their dynamics, we must first define their actual presence in the natural bacterial assemblage. Here we found varying distribution profiles of sul genes in "colony forming bacte...