نتایج جستجو برای: drug metabolism
تعداد نتایج: 792396 فیلتر نتایج به سال:
Pharmacokinetics, Dynamics & Metabolism, Pfizer, La Jolla, California (E.K.), Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech, South San Francisco, California (A.V.K.), Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland (M.W.), Drug Metabolism, Pharmacokinetics & Bioanalysis Department, AbbVie, Wo...
Mucoadhesive drug delivery systems extent the residence time of dosage form at site application or absorption. They facilitate an intimate touch shape with underlying absorption floor and accordingly enhance healing overall performance drug. These structures continue to be in near tissue, mucous membrane, liberating on movement action main a bioavailability growth each nearby systemic effect. T...
Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and transport influence the cytotoxic effects of antineoplastic agents in target tumor cells and normal host tissues. This article summarizes several state-of-the-art approaches to enhancing the effectiveness and safety of cancer therapy bas...
137 Translational I N this series of special themed editions of the Journal of Gerontology Biological Sciences and Medical Sciences, reviews and commentaries have been solicited that focus on the basic biology, animal models, translational research, physiology, epidemiology, and public health aspects of aging. This emphasizes the multidisciplinary and translational nature of modern aging resear...
Ethnic differences in drug metabolism are well documented for a number of drugs. The molecular mechanisms responsible for ethnic differences in drug metabolism have been partly clarified because of the advances in molecular biology in recent years. Gene dosage determines the drug metabolism as demonstrated for S-mephenytoin and diazepam metabolism. Genotype analysis indicates a different freque...
The liver is the most important site of drug metabolism and patients with liver disease might be expected to have a reduced capacity to metabolize drugs. The rates of elimination of extensively metabolized drugs such as the barbiturates, diazepam, tolbutamide, isoniazid, phenylbutazone, rifampicin, lignocaine, paracetamol, aminopyrine, antipyrine and pethidine have been measured in patients wit...
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