aims: cholera is an acute diarrheal disease that can lead to severe dehydration and death. antibiotic resistance is a big challenge in infective disease like cholera. the present study aimed to understand the characteristics and trends of antibiotic resistance of v. cholerae isolations in and around kashan, iran. instrument & methods: in this descriptive cross-sectional study, samples were gath...

with the aim of obtaining information about drug-drug interaction (ddi) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and controlled-potential coulometry. the reaction between n-acetyl-p-ben...

rational prescribing increases the quality of health care and patient outcomes. in this study, the quality of drug prescription in specialist physicians in isfahan province of iran was assessed for evaluating the rational use of drugs and improving the therapeutic outcomes.this retrospective survey was conducted on a total of 7999530 prescriptions from all general and specialist physicians. the...

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

background: restless and violent behaviors are common in emergency departments (eds), which need therapeutic interventions in most of the times. the first-generation anti-psychotic drugs are one of the most applicable therapeutic agents in the management of such patients, but their use has some limitations. some studies suggest midazolam as an alternative medicine. therefore, this study was per...

the aim of the present study was to evaluate the pattern of vancomycin administration in the hematology-oncology ward of nemazee hospital, shiraz, iran. study criteria were developed to assess the several parameters involved in vancomycin therapy. these parameters include the appropriateness of drug usage, dosage, duration of therapy, monitoring for toxicity and serum concentration monitoring. ...

this commentary discusses pertinent issues from hyosun kim’s paper on online prescription drug promotion. the study is well-designed and the findings highlight some of the consequences of the food and drug administration’s (fda’s) decision to deregulate online advertising of prescription drugs. while kim’s findings confirm some of the early concerns, they also provide a perspective of implement...

extensively drug-resistant tuberculosis (xdr-tb) is a new challenge for tuberculosis control programs. lack of effective drugs and high rate of failure in treatment and mortality is a major threat for public health. treatment of this serious infection needs well-designed individualized dosage regimen and powerful national tb program. in this review we will describe the xdr-tb definition and its...

A recovery model of depression (Needles & Abramson, 1990 Journal of Abnormal Psychology, 99, 156-165) proposes that depressed individuals who exhibit an enhancing attributional style for positive events (i.e. make stable, global attributions) will be more likely to regain hopefulness and, thereby, recover from depression when positive events occur. While only a few studies have directly tested ...

An important problem in population genetics is the determination of the level of genetic organization to which fitness measures can be ascribed that yield an adequate description or prediction of the outcome of selection in populations. To study this problem, we used two strains of Drosophila merca torum (S-1-Im and O-3-Im) that are capable of both sexual and parthenogenetic reproduction, a fea...