Cancer Stem Cells In article number 2100985 by Jia Sun, Xin Han, and co-workers, a microfluidic tandem mechanical sorting strategy is reported to enrich cancer stem cells (CSCs) with high flexibility low adhesive capacity. The method achieves robust isolation of CSCs in high-throughput, label-free manner, which has promising potential for facilitating drug screening targeting developing novel t...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

introduction: the aim of this study was to compare the microleakage of beneath the orthodontic brackets bonded with 3 different bonding techniques and evaluate the effect of thermocycling. methods: one hundred and twenty premolars were randomly divided into 6 groups, received the following treatment: group 1: 37% phosphoric acid gel+unite primer+unite adhesive, group 2: 37% phosphoric acid gel+...

Introduction: Studies have suggested that sodium fluoride (NaF) has an inhibitory effect on the activity of endogenous matrix metalloproteinase enzymes. This study assessed the effect of a fluoride-containing adhesive on microtensile bond strength (µTBS) over time. Material & Methods: In this experimental study, 36 extracted  third molars were used to evaluate the µTBS of...

abstract statement of problem: there is no enough published data about the shear bond strength of resin modified glass ionomer adhesives on caries-affected primary tooth dentin excavated using minimally invasive systems. objectives: to evaluate the shear bond strength of 2 different adhesives (one resin modified glass ionomer and one resin) using two caries removal techniques on healthy and car...

Hydrophobic grade fumed silicas are generally used in tabletting as lubricants. They are also found to retard the release of pharmaceutical actives. This is because of their hydrophobic nature, which gives good cohesive and adhesive properties. considering this point it was thought that they could be used as dry coating agents for solid dosages forms. The model drug selected for this work was p...

Nowadays about 74% of drugs are taken orally and found not to be as effective required. To improve such characters transdermal drug delivery system was emerged. Drug through the skin attain a systemic effect is commonly known differs from traditional topical delivery. Transdermal systems (TDDS) dosage forms involves transport viable epidermal or dermal tissues for local therapeutic while very m...

Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity.The objective of this article is to review buccal drug delivery by discussing the structure and environment of the oral mucosa and highlighting the mechanisms of drug permeation and methodology in evaluating buccal formulations. This review also highlights a brief descri...

BACKGROUND AND AIM: According to the effect of the adhesive and substrate type on the bond strength, examination of the adhesive is required in all aspects. The aim of this study was to evaluate the shear bond strength of different adhesive systems to normal dentin (ND) and caries affected dentin (CAD) in permanent teeth. METHODS: Thirty extracted molars with small occlusal caries were selected...