Planarians display a concentration-related reduction in locomotor activity following their spontaneous withdrawal from opioids, cannabinoids, stimulants and benzodiazepines. This suggests that planarians display a withdrawal-like behavior that can be quantified as a reduction in locomotor activity. Because withdrawal-like behavior in previous studies has been quantified only following the cessa...

The lethal and sublethal effects of 1-/?-D-arabinofuranosylcytosine (ara-C) were studied in Sarcoma 180 in vitro in relation to drug concentration and drug exposure duration. Drug le thality was found to be dependent on both drug concentration and drug exposure duration. These studies confirmed that radioautographic grain counts reflect relative rates of DMA synthesis in individual cells. When ...

Neoral cyclosporine has better absorption characteristics than the original Sandimmun formulation. This has allowed Neoral to be administered orally in circumstances where Sandimmun had been ineffective, including the postoperative phase of liver transplantation. Sampling strategies, such as the measurement of drug concentration 2 h after oral administration, have been used in a variety of sett...

We assessed relations among depression, conduct disorder, and drug use from adolescence to young adulthood, and evaluated whether exposure to violence contributed to disorder co-occurrence. We used data from the Project on Human Development in Chicago Neighborhoods. Respondents were 12-15 years old in 1995-1997 (N = 1,517), and were reinterviewed in 1997-2000 (n = 1,315), and 2000-2002 (n = 1,2...

OBJECTIVE To estimate the effect of maternal illicit and prescription drug use on neonates in Washington State between 2000 and 2008. METHODS We used state-linked birth certificate and hospital discharge (mother and neonate) data to calculate prenatal drug exposure and neonatal abstinence syndrome rates, and compared state neonatal abstinence syndrome rates with national-level data from the N...

results mean age of the participants was about 35 years, and mean duration of marriage was 14 years. drug dependence of the husband (p = 0.010) and lower monthly income of the family (p = 0.007) predicted the higher level of anxiety among the participants, while older age (p = 0.031), shorter marital duration (p = 0.016), and lower educational level (p = 0.045) in addition to spousal drug depen...

The effects of hyperbaric oxygen (HPO) exposure on the cytotoxicity of Adriamycin (ADM) and nitrogen mustard have been examined in Burkitt's lymphoma cells (P3J) in vitro. Exposure of cells to 3 atmospheres of pressure HPO for 2 hr produces inhibition of DNA synthesis and mitosis. Simultaneous exposure to HPO and ADM results in decreased cytotoxicity compared to drug treatment alone. However, e...

The paper presents the results of a study extinction spectra (350–900 nm) aqueous solutions modern chlorine-containing photosensitizing drugs for photodynamic therapy “Chloderm" (Chloderm, Russia) and "Chloderm with hyaluronic acid" before after irradiation by visible light wavelengths 405 nm, 450 656±10 exposure time 0–20 min intensity 0–200 mW/cm 2 . It is demonstrated that addition acid does...