Triptoreline is a potent agonist of luteinizing hormone-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Frequent injection of drug decreases patients’ compliance. The present study describes the formulation of a sustained release microparticulate drug delivery system containing triptoreline acetate, using poly (D,L lacti...

BACKGROUND For premature neonates needing parenteral nutrition (PN), a balanced lipid supply is crucial. The authors hypothesized that a lipid emulsion containing medium-chain triglycerides (MCTs) and soybean, olive, and fish oils would be as safe and well tolerated as a soybean emulsion while beneficially influencing the fatty acid profile. METHODS Double-blind, controlled study in 53 neonat...

Abstract A method was proposed for preparing multiple emulsions based on a double parallel-crank mechanism. The dispersed phase flows into the glass capillary, and capillary driven to make circular motion via connecting crank structure. Then, external shears through mechanism prepare water in oil (W/O) droplets, process of generation droplets simulated by CFD. effects rotating speed, diameter, ...

Colloidosomes are microcapsules whose shell consists of densely packed colloidal particles. Their physical properties such as permeability, mechanical strength, and biocompatibility can be precisely controlled through the proper choice of colloids and preparation conditions for their assembly. The high degree of control over their physical properties makes colloidosomes attractive structures fo...

OBJECTIVES To examine whether a mixed lipid emulsion reduces the incidence of parenteral nutrition associated cholestasis (PNAC) in extremely low birth weight (ELBW, <1000 g) infants. STUDY DESIGN This double-blind randomized trial of 230 ELBW infants (June 2012-October 2015) was performed at a single level IV neonatal intensive care unit. Patients received either a mixed lipid emulsion compo...

Triptoreline is a potent agonist of luteinizing hormone-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Frequent injection of drug decreases patients’ compliance. The present study describes the formulation of a sustained release microparticulate drug delivery system containing triptoreline acetate, using poly (D,L lacti...