نتایج جستجو برای: dota

تعداد نتایج: 2399  

Journal: :CoRR 2017
Gui-Song Xia Xiang Bai Jian Ding Zhen Zhu Serge J. Belongie Jiebo Luo Mihai Datcu Marcello Pelillo Liangpei Zhang

Object detection is an important and challenging problem in computer vision. Although the past decade has witnessed major advances in object detection in natural scenes, such successes have been slow to aerial imagery, not only because of the huge variation in the scale, orientation and shape of the object instances on the earth’s surface, but also due to the scarcity of wellannotated datasets ...

2016
Carlo Diaferia Flavia Anna Mercurio Cinzia Giannini Teresa Sibillano Giancarlo Morelli Marilisa Leone Antonella Accardo

Water soluble fibers of PEGylated tetra-phenylalanine (F4), chemically modified at the N-terminus with the DOTA chelating agent, have been proposed as innovative contrast agent (CA) in Magnetic Resonance Imaging (MRI) upon complexation of the gadolinium ion. An in-depth structural characterization of PEGylated F4-fibers, in presence (DOTA-L6-F4) and in absence of DOTA (L6-F4), is reported in so...

Journal: :Inorganic chemistry 2001
C A Chang Y L Liu C Y Chen X M Chou

The molecular mechanics and dynamics calculations, kinetics, and laser-excited luminescence studies were carried out for trivalent lanthanide (Ln(3+)) complexes of macrocyclic polyaminopolycarboxylate ligands TETA and DOTA (where TETA is 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid and DOTA is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) to further understand the obs...

2016
Ruizhi Wang Yu Luo Shuohui Yang Jiang Lin Dongmei Gao Yan Zhao Jinguo Liu Xiangyang Shi Xiaolin Wang

Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. The early and effective diagnosis has always been desired. Herein, we present the preparation and characterization of hyaluronic acid (HA)-modified, multifunctional nanoparticles (NPs) targeting CD44 receptor-expressing cancer cells for computed tomography (CT)/magnetic resonance (MR) dual-mode imaging. We first mod...

2015
Liyun Lai Raymond Ong Juntao Li Salvatore Albani

CyTOF enables the study of the immune system with a complexity, depth, and multidimensionality never achieved before. However, the full potential of using CyTOF can be limited by scarce cell samples. Barcoding strategies developed based on direct labeling of cells using maleimido-monoamide-DOTA (m-DOTA) provide a very useful tool. However, using m-DOTA has some inherent problems, mainly associa...

2013
Volkan Beylergil Patrick G. Morris Peter M. Smith-Jones Shanu Modi David Solit Clifford A. Hudis Yang Lu Joseph O’Donoghue Serge K. Lyashchenko Jorge A. Carrasquillo Steven M. Larson Timothy J. Akhurst

OBJECTIVE 68Ga-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-F(ab')2-trastuzumab [68Ga-DOTA-F(ab')2-trastuzumab] has been developed at our institution as a positron imaging reagent for assessing human epidermal growth factor receptor 2 (HER2) expression status by in-vivo imaging. Initial studies on animals demonstrated promising results in the monitoring of treatment resp...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007
Weibo Cai Kai Chen Zi-Bo Li Sanjiv S Gambhir Xiaoyuan Chen

UNLABELLED To date, the in vivo imaging of quantum dots (QDs) has been mostly qualitative or semiquantitative. The development of a dual-function PET/near-infrared fluorescence (NIRF) probe can allow for accurate assessment of the pharmacokinetics and tumor-targeting efficacy of QDs. METHODS A QD with an amine-functionalized surface was modified with RGD peptides and 1,4,7,10-tetraazacyclodoc...

Journal: :EJNMMI research 2016
Aikaterini Kaloudi Berthold A Nock Emmanouil Lymperis Roelf Valkema Eric P Krenning Marion de Jong Theodosia Maina

BACKGROUND We have recently shown that treatment of mice with the neutral endopeptidase (NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of biodegradable radiopeptides. For the truncated gastrin radiotracer [(111)In-DOTA]MG11 ([(DOTA)DGlu(10)]gastrin(10-17)), this method led to impressively high tumor-to-kidney ratios. Translation of this concept in the clinic r...

2015
Zhuxian Zhou Mohammed Qutaish Zheng Han Rebecca M Schur Yiqiao Liu David L Wilson Zheng-Rong Lu

Metastasis is the primary cause of death in breast cancer patients. Early detection of high-risk breast cancer, including micrometastasis, is critical in tailoring appropriate and effective interventional therapies. Increased fibronectin expression, a hallmark of epithelial-to-mesenchymal transition, is associated with high-risk breast cancer and metastasis. We have previously developed a penta...

2015
Botshelo B Mokaleng Thomas Ebenhan Suhas Ramesh Thavendran Govender Hendrik G Kruger Raveen Parboosing Puja P Hazari Anil K Mishra Biljana Marjanovic-Painter Jan R Zeevaart Mike M Sathekge

Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An alarming shortage of infection-selective radiopharmaceuticals exists for overcoming the diagnostic limitations with unspecific tracers such as (67/68)Ga-citrate or (18)F-FDG. We report here TBIA101, an antimicrobial peptide derivative that was conjugated to DOTA and rad...

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