Hemoglobin (Hb) adducts, formed by the neurotoxic agent acrylamide (AA) and its genotoxic metabolite glycidamide (GA), were measured in the rat by means of a method for simultaneous determination of the adducts formed to cysteine. A novel, nonlinear dosimetric model was developed to describe Hb adduct formation. This model incorporates the saturable kinetics of the metabolic conversion in vivo ...

The Source Production & Equipment Co. (SPEC) model M-15 is a new Iridium-192 brachytherapy source model intended for use as a temporary high-dose-rate (HDR) brachytherapy source for the Nucletron microSelectron Classic afterloading system. The purpose of this study is to characterize this HDR source for clinical application by obtaining a complete set of Monte Carlo calculated dosimetric pa...

The crystalline substances are the most used for Thermoluminescent Dosimetry (TLD) purposes. The crystalline structure allows for a controlled impurification with activators in order to improve their dosimetric parameters. The activators introduced into the crystalline network [1], enhance the number of electrons and hole traps inside the forbidden band. In the first step, immediately after the...

Purpose: To evaluate planning quality and dosimetric differences of clinically deliverable 3D conformal plans generated from Tomotherapy with TomoDirectTM (TD) and conventional field-in-field approach in prone breast treatment. Materials and methods: Total of twelve randomly selected early stage left breast patients who went through lumpectomy and were previously treated on traditional Linear A...

Introduction Low dose rate brachytherapy sources have been widely used for interstitial implants in tumor sites, particularly in prostate. Dosimetric characteristics of a new IrSeed 125I brachytherapy source have been determined using the LiF thermoluminescent dosimeter (TLD) chips. Materials and Methods Dose rate constant, radial dose function, and anisotropy function around the IrSeed 125I so...

Introduction: Breast cancer is becoming more frequently diagnosed at early stages with improved long-term outcomes. Radiation-related heart disease and lung cancer can occur following radiotherapy for breast cancer. The aim of this study was to evaluate some dosimetric parameters of heart and lung during whole breast radiotherapy. Materials and Methods: Twenty...

BACKGROUND Volumetric-modulated Dynamic WaveArc therapy (VMDWAT) is a non-coplanar continuous volumetric modulated radiation therapy (VMAT) delivery technique. Here, we monitored mechanical errors and their impact on dose distributions in VMDWAT using logfiles throughout the course of treatment. METHODS Fifteen patients were enrolled (2 skull base tumor patients and 13 prostate cancer patient...

This study investigated whether conformal radiotherapy affects hepatitis B virus (HBV) reactivation, and the risk factors for HBV reactivation in patients with HBV-related hepatocellular carcinoma (HCC). Sixty-nine patients with HCC were included in this retrospective study. Before radiotherapy (RT), all patients underwent imaging examinations and some baseline examinations, including CBC, live...

As complexity for treating patients increases, so does the risk of error. Some publications have suggested that record and verify (R&V) systems may contribute in propagating errors. Direct data transfer has the potential to eliminate most, but not all, errors. And although the dosimetric consequences may be obvious in some cases, a detailed study does not exist. In this effort, we examined pote...