Animal experiments are generally conducted at higher dose levels than anticipated human dose levels in order to elicit otherwise subtle changes in reproduction or developmental effects with relatively few animals. Based on animal data, regulatory strategy generally has been to postulate a no-observed-effect level (NOEL) for toxic effects and to divide this by a safety factor, usually 100, to es...

introduction: the main purpose of this study was to compare transient ischemic dilation (tid) ratios in spect-low dose ct and spect myocardial perfusion imaging (mpi) by application of different quantitative programs and quantify the possible shift in the upper normal limits of tid ratio in the spect-ct mpi. methods: 149 patients with low pre-test probability for coronary artery disease (cad),...

background: changes in body composition may be used for monitoring progression/ regression of a disease. prompt γ-rays in vivo neutron activation analysis (ivnaa) has been widely used for the measurement of body composition in recent years. objective: in this paper, we tried to improve the safety of ivnaa operator. methods: the most important factor for reducing the operator receiving dose is t...

BACKGROUND Dexmedetomidine can be used for the prevention of emergence agitation (EA) in children. However, an inadequate dose of dexmedetomidine can induce prolonged sedation and cardiovascular complications. The aim of this study was to evaluate the effective dose of dexmedetomidine for the prevention of EA after desflurane anesthesia for patients undergoing a tonsillectomy or adenoidectomy. ...

Background: The aim of the study was to analyze the effective dose record of occupationally exposed radiation workers at Bahawalpur Institute of Nuclear Medicine and Oncology department. Materials and Methods: Annual effective doses of occupationally exposed workers were measured by film badge dosimetry by sending the dosimeters to Radiation Dosimetry Laboratory (RDL), Pakistan Institute of Nuc...