Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in mo...

~ The high temperature peaks (TL peaks 6-7) of TLD-600 are known to have higher responses to high LET radiation than to low LET radiation. These high temperature peak characteristics were studied for the automatic readerannealed Harshaw albedo neutron TLD. The high temperature peaks response is linear for neutrons over the dose equivalent range tested (0.05-3 mSv of a 252Cf source moderated by ...

PURPOSE To evaluate a new calculation model estimating the equivalent dose at 2 Gy (EQD2) taking into account dose gradient in high dose rate interstitial brachytherapy (HDRIB). MATERIAL AND METHODS Forty dose-volume histograms (DVHs) of breast (20 pts) and prostate (20 pts) cancer dose distributions were reviewed. Physical prescribed doses (PPD) were 34 Gy (10f/5d) and 18 Gy (6f/2d) for brea...

Most investigations of the comparative nephrotoxicities of aminoglycosides in animals have utilized large multiples of the human dose. Furthermore, many of these assessments have used only one or two dose levels and have not described a dose-response comparison among antibiotics. Because of this lack of comparative dose-response data over a range of low multiples of the human dose, the nephroto...

Introduction: Due to nuclear interactions between the tissues and high-energy protons, the particles, including neutrons, positrons, and photons arise during proton therapy. This study aimed at investigating the dose distribution of proton and secondary particles, such as positrons, neutrons, and photons using the Monte Carlo method. Material and Methods:<...

A study on the evaluating equivalent damping and response modification factors of frames equipped by Pall Friction Dampers is presented. To do so, buildings with various stories were considered. Nonlinear and linear dynamic time history analysis has been performed to evaluate equivalent damping for Pall Friction Dampers. Ground motions with various frequency characteristics scaled with Iranian ...

BACKGROUND AND PURPOSE Although FDG-avid tumors are recognized as a potential target for dose escalation, there is no clear basis for selecting a boost dose to counter this apparent radioresistance. Using a novel analysis method, based on the new concept of an outcome-equivalent dose, we estimate the extra dose required to equalize local control between FDG-avid and non-avid head and neck tumor...

Monte Carlo simulations have been carried out using the FLUKA code to improve the neutron ambient dose equivalent [H*(10)] response of the ZReC (zirconium-lined portable neutron counter responding satisfactorily to neutrons up to 1 GeV) by introducing various neutron absorbers in the system such as cadmium, gadolinium, natural boron, enriched (10)B and borated polythene. It was found that ZReC ...

Background: To evaluate the risk involved, there is need to know the quantum of personnel exposures in whole service. Dose reports from an Oncology Centre over 7 block periods, 5 years each from 1979 till 2013 are analyzed. Materials and Methods: Personnel monitoring (PM) reports till 1990s with film badges and later thermoluminescent (TL) badges (CaSo4.Dy) were evaluated. 35 years total servic...