AIM To compare the efficacy and safety of omeprazole-domperidone combination vs omeprazole monotherapy in gastroesophageal reflux disease (GERD). METHODS In a comparative, randomized controlled, phase 4 study, outpatients with GERD were randomly allocated to either group 1 (omeprazole 20 mg + domperidone 30 mg) or group 2 (omeprazole 20 mg) in an equal ratio; 2 capsules daily in the morning w...

A simple, precise, rapid, selective, (HPTLC) method has been established for simultaneous analysis of Domperidone (DMP) and paractamol (PAR) in tablet dosage forms. The Chromatographic separation was performed on per coated silica gel 60 GF254 .plate with acetone -methanolcarbon tetrachloride 5:5:1(V/V) as mobile phase. The plates were developed to a distance of 8.0 cm at ambient temperature. T...

E xclusive breastfeeding for the fi rst 6 months of life is well recognised as the optimal form of nutrition to support the growth and development of term and preterm infants. 1 Whether real or just perceived, low milk supply is the most commonly reported reason for early discontinuation of breastfeeding. 2 This is despite the fact that most mothers are able to produce suffi cient quantities of...

Copyright  2015 irjpbs Objective: To compare the efficacy and safety of levosulpiride with dompenidone in patients with functional dyspepsia Material & Method: It was a prospective, double blind, randomized study conducted on 182 patients in two groups of 91 each. Group A: levosulpiride 25mg TID daily orally for 4 weeks, Group B: Domperidone 10mg TID daily orally for 4 weeks. Individual sympto...

Bromocriptine, a dopamine agonist, is known to lower cardiovascular mortality in L-dopa-treated patients with Parkinson's disease, probably by reducing the cardiac sympathetic activity. We aimed at unmasking the central effects of bromocriptine on the heart by power spectrum analysis. Ten healthy subjects (aged 31+/-2 years) in supine and sitting positions were evaluated after the administratio...

To evaluate the PRL secretory mechanism in patients with PRL-secreting adenoma (PRL-oma), plasma PRL responses to dopamine (DA) were studied in these cases and in normal subjects. Plasma PRL values showed clear decreases during the infusion of DA (5 micrograms/kg/min for 90 min) in both 6 normal and 7 PRL-oma subjects (%decrease: 43.8 +/- 3.9% vs. 53.9 +/- 5.6%; NS) and postinhibitory increases...

Commercially available domperidone orodispersible tablets (ODT) are intended for immediate release of the drug, but none of them have been formulated for sustained action. The aim of the present research work was to develop and evaluate orodispersible sustained release tablet (ODT-SR) of domperidone, which has the convenience of ODT and benefits of controlled release product combined in one. Th...

In view of therapeutic advances, we carried out meta-analysis of results from 18 randomized, controlled clinical studies to update a previous meta-analysis and to provide an overview of clinical trials involving treatment of functional dyspepsia. The studies were included only if they satisfied inclusion and exclusion criteria and assessed treatment of functional dyspepsia with the antisecretor...