Molecular computing executed via local interactions of spatially contiguous sets of molecules has potential advantages of (i) speed due to increased local concentration of reacting species, (ii) generally sharper switching behavior and higher precision due to single molecule interactions, (iii) parallelism since each circuit operates independently of the others and (iv) modularity and scalabili...

As a computational model to be simulated in a DNA computing context, Boolean circuits are especially interesting because of their parallelism. Simulations in concrete biochemical computing settings have been given by [OR96] and [AD97]. In this paper, we show how to simulate Boolean circuits by finite splicing systems, an abstract model of enzymatic recombination ([Hea87], [Gat94], [Pǎu96a]). We...

This paper is motivated by a method used for DNA sequencing by hybridization presented in [Jacek Blazewicz, Marta Kasprzak, Computational complexity of isothermic DNA sequencing by hybridization, Discrete Appl. Math. 154 (5) (2006) 718–729]. This paper presents a class of digraphs: the quasi-adjoint graphs. This class includes the ones used in the paper cited above. A polynomial recognition alg...

Biomedical researchers have long studied biological pathways in hopes of further understanding the effect of disease on critical events and interactions within these pathways. In recent years, new bioinformatic approaches to pathway prediction have been developed, taking advantage of the availability of vast amounts of microarray data and efficient machine learning techniques. Recent years have...

While DNA circuits are becoming increasingly useful as signal transducers, their utility is inhibited by their slow catalytic rate. Here, we demonstrate how RecA, a recombination enzyme that catalyzes sequence specific strand exchange, can be used to increase circuit rates up to 9-fold. We also show how the introduction of RNA into DNA circuits further controls the specificity of RecA strand ex...

a high accurate and low-voltage analog cmos current divider which operates with a single power supply voltage is designed in 0.18µm cmos standard technology. the proposed divider uses a differential amplifier and transistor in triode region in order to perform the division. the proposed divider is modeled with neural network while tlbo algorithm is used to optimize it. the proposed optimization...

This study introduces an optical DNA-based logic circuit that mimics a half-subtractor. The system contains an Au-surface immobilized molecular-beacon molecule that serves as a dual-gate molecule and outputs two series of fluorescence signals following Boolean INH and XOR patterns after interacting with one or two single-stranded DNA molecules as input. To the best of our knowledge, the system ...

Background: Obesity is associated with chronic inflammation in obese subjects, which leads to an increase of inflammatory cytokines. This study aimed to evaluate the effect of different intensity circuit resistance training on levels of interleukin 1 beta and interleukin-10 in obese men. Methods: In a semi-experimental trial during May to August 2020, 44 obese men from Tehran city were selecte...