DNA double-strand breaks (DSBs) are the most deleterious form of damage and repaired through non-homologous end-joining (NHEJ) or homologous recombination (HR). Repair initiation, regulation communication with signaling pathways require several histone-modifying chromatin-remodeling complexes. In budding yeast, this involves three primary complexes: INO80-C, which is primarily associated HR, SW...

background hypervariability of hcv proteins is an important obstacle to design an efficient vaccine for hcv infection. multi-epitope vaccines containing conserved epitopes of the virus could be a promising approach for protection against hcv. objectives cellular and humoral immune responses against multi-epitope dna and peptide vaccines were evaluated in balb/c mice. materials and methods in th...

A novel extreme thermophilic and piezophilic chemoorganoheterotrophic archaeon, strain EXT12c T , was isolated from a hydrothermal chimney sample collected at depth of 2496 m the East Pacific Rise 9° N. Cells were strictly anaerobic, motile cocci. The grew NaCl concentrations ranging 1 to 5 % (w/v; optimum, 2.0%), pH 6.0 7.5 (optimum, 6.5–7.0), temperatures between 60 95 °C 80–85 °C), pressures...