background: extracellular vesicles are particles ranged from 30 nm to 5µm and subcategorized into three groups; exosomes, microvesicles and apoptotic bodies, each of which have different biological impact. lack of a standard method for the detection and isolation of mvs has led to a challenging issue that is a worth considering. in this study, we isolated mvs from the conditioned medium of uc-m...

Recently, attempts have been done to formalize Semantic Matchmaking, the process of finding potential matches between demands and supplies based on their logical relations with reference to a common ontology, in Description Logics (DLs). We extend the formalization to Packages-based Description Logics (P-DLs), modular extensions of DLs, in order to perform the matchmaking operation in contexts ...

We previously found that brain-derived neurotrophic factor (BDNF)-haplodeficient mice exhibit greater ethanol-induced place preference and psychomotor sensitization, and greater ethanol consumption after deprivation, than control mice. We further observed that, in mice, voluntary ethanol intake increases BDNF expression in the dorsal striatum (DS). Here, we determined whether BDNF within the DS...

Purpose – Most digital libraries (DLs) are now available online. They also provide the Z39.50 standard protocol which allows computer-based systems to effectively retrieve information stored in the DLs. The major difficulty lies in inconsistency between database schemas of multiple DLs. This paper presents a system known as Argumentation-based Digital Library Search (or ADLSearch) which facilit...

We present Bayesian Description Logics (BDLs): an extension of Description Logics (DLs) with contextual probabilities encoded in a Bayesian network (BN). Classical DL reasoning tasks are extended to consider also the contextual and probabilistic information in BDLs. A complexity analysis of these problems shows that, for propositionally closed DLs, this extension comes without cost, while for t...

Recent results show that ontology consistency is undecidable for a wide variety of fuzzy Description Logics (DLs). Most notably, undecidability arises for a family of inexpressive fuzzy DLs using only conjunction, existential restrictions, and residual negation, even if the ontology itself is crisp. All those results depend on restricting reasoning to witnessed models. In this paper, we show th...

............................................................................................................................... v List of papers ........................................................................................................................ ix Summary of papers and author contribution ......................................................................... x Introducti...

BACKGROUND A simple method for the measurement of LDL particle sizes is needed in clinical laboratories because a predominance of small, dense LDL (sd LDL) has been associated with coronary heart disease. We applied dynamic light scattering (DLS) to measure lipoprotein particle sizes, with special reference to sd LDL. METHODS Human serum lipoproteins isolated by a combination of ultracentrifu...

Description Logics are currently advancing to become a very prominent paradigm for representing knowledge bases in a variety of application areas. Central to leveraging them for corresponding systems is the provision of a favourable balance between expressivity of the knowledge representation formalism on the one hand, and runtime performance of reasoning algorithms on the other. Due to this, H...

We have developed a unique DNA-assembled gold nanoparticles (AuNPs) dimer for dynamic light scattering (DLS) sensing of transcription factors, exemplified by estrogen receptor (ER) that binds specifically to a double-stranded (ds) DNA sequence containing estrogen response element (ERE). Here, ERE sequence is incorporated into the DNA linkers to bridge the AuNPs dimer for ER binding. Coupled wit...