Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. One of the hallmarks of gastric cancer is chromosomal instability resulting in abnormal DNA copy number changes throughout the genome. Mixed gastric carcinomas constitute a rare histological entity, contai...

BACKGROUND Subtelomeres, regions proximal to telomeres, exhibit characteristics unique to eukaryotic genomes. Genes residing in these loci are subject to epigenetic regulation and elevated rates of both meiotic and mitotic recombination. However, most genome sequences do not contain assembled subtelomeric sequences, and, as a result, subtelomeres are often overlooked in comparative genomics. ...

Ideal magnetohydrodynamic (MHD) equations consist of a set of nonlinear hyperbolic conservation laws, with a divergence-free constraint on the magnetic field. Neglecting this constraint in the design of computational methods may lead to numerical instability or nonphysical features in solutions. In our recent work (Journal of Computational Physics 230 (2011) 48284847), second and third order ex...

Laser diode beam divergence is the main parameter for beam shaping and fiber optic coupling. Increasing the waveguide layer thickness is the conventional method to decrease the beam divergence. In this paper, the broadened asymmetric waveguide is introduced to decrease the divergence without increasing the optical power. The asymmetric waveguide was used to shift the vertical optical field to n...

introduction: assessing quality of life for patients with shoulder instability may be essential because of the negative impacts of the disease on patient’s life. the aim of the present study, therefore,  was  to  assess  the  internal  validity  and  consistency,  test-retest  reliability,  and convergent validity of the persian version of the oxford shoulder instability score (osis). material ...

Recent experiments have shown intriguing regions of intense luminescence or ‘hotspots’ in the vicinity of triple-point shear layers in propagating gaseous detonation waves. Localized explosions have also been observed to develop in these fronts. These features were observed in higher effective activation energy mixtures, but not in lower effective activation energy mixtures. The increased lead ...

We investigate both theoretically and numerically the consistency between nonlinear discretization in full order models (FOMs) reduced (ROMs) for incompressible flows. To this end, we consider two cases: (i) FOM-ROM consistency, i.e., when use same nonlinearity FOM ROM; (ii) inconsistency, different discretizations ROM. Analytically, prove that while yields optimal error bounds, inconsistency a...

The n-body instability is investigated with the soft-sphere discrete element method. divergence of nearby trajectories quantified by dynamical memory time. Using inverse proportionality between time and largest Lyapunov exponent, method results are compared to previous hard-sphere molecular dynamics data for first Good agreement observed at low concentrations degree shown increase asymptoticall...

Eyelets, capstans and cylindrical surfaces are often used in thread, fiber and paper handling machinery to guide the axially moving element. In addition to providing positional control, these “guides” introduce dry friction forces that alter the vibration and stability characteristics of the system. This paper examines the lateral response of a string that slides through an elastically supporte...

This study experimentally investigated the instability of flow impingement in a cerebral aneurysm, which was speculated to promote the degradation of aneurysmal wall. A patient-specific, full-scale and elastic-wall replica of cerebral artery was fabricated from transparent silicone rubber. The geometry of the aneurysm corresponded to that found at 9 days before rupture. The flow in a replica wa...