The CO2-brine dissolution homogenizes the distribution of residual CO2 and reduces the leakage risk in the saline aquifer. As a key parameter to immobilize the free CO2, the dissolution rate of CO2-brine could be accelerated through mechanisms like diffusion and dispersion, which are affected by the subsurface condition, pore structure, and background hydrological flow. This study contributed t...

The aim of this study was to enhance the dissolution rate of efavirenz using solid dispersion systems (binary and ternary). A comparison between solvent and fusion method was also investigated. Solid dispersions of efavirenz were prepared using polyethylene glycol 8000, polyvinylpyrrolidone K30 alone and combination of both. Tween 80 was incorporated to obtain a ternary solid dispersion system....

piroxicam has two different crystalline forms (known as needle and cubic forms), that they are different in physicochemical properties such as biological solubility. in the current research, using taguchi experimental design approach the influences of five operating variables on formation of the piroxicam polymorph shapes in recrystallization were studied. the variables include type of solvent,...

[1] Water-rock interactions within variable aperture fractures can lead to dissolution of fracture surfaces and local alteration of fracture apertures, potentially transforming the transport properties of fractures over time. Because fractures often provide dominant pathways for subsurface flow and transport, developing models that effectively quantify the role of dissolution on changing transp...

Dissolution testing measures the rate of drug substance release into solution, impacting the extent of drug absorption. Drug manufacturers and regulatory agencies use dissolution testing to identify drug products that do not meet the desired clinical performance. Formulation composition and manufacturing processes can impact the material attributes of a drug product, which directly affect the d...

PURPOSE To evaluate the influence of co-administered vehicles on in vitro dissolution in simulated gastric fluid of crushed immediate release tablets as an indicator for potential drug bioavailability compromise. METHODS Release and dissolution of crushed amlodipine, atenolol, carbamazepine and warfarin tablets were tested with six foods and drinks that are frequently used in the clinical set...

A fully coupled hydrological–mechanical–chemical (HMC) model is developed and applied to explain enigmatic spontaneous changes in permeability that develop within a fracture in limestone under simulated in situ conditions (Water Resour Res 2004;40:W03502). The water flow-through test was concurrently monitored for water and dissolved mineral mass efflux and periodically imaged by X-ray CT to pr...

Because aggregated diatoms sink rapidly through the water column, leaving little time for dissolution, aggregation influences the balance between recycling of biogenic silica (bSiO2) and its sedimentation and preservation at the seafloor. Additionally, aggregation may directly impact dissolution rates of opal. Laboratory experiments were conducted to investigate the influence of aggregation on ...

Aqueous dissolution of silicate glasses and minerals plays a critical role in global biogeochemical cycles and climate evolution. The reactivity of these materials is also important to numerous engineering applications including nuclear waste disposal. The dissolution process has long been considered to be controlled by a leached surface layer in which cations in the silicate framework are grad...