Disseminated Mycobacterium avium complex (MAC) is the most common systemic bacterial infection in patients with acquired immunodeficiency syndrome (AIDS) in developed countries; however, it is reported to be uncommon in Africa. The role of a prior history of tuberculous disease, and the presence of a bacille Calmette-Guerin (BCG) scar, in preventing disseminated MAC is controversial. The aims o...

Pathologic diagnosis of Mycobacterium infection from bony specimens was recorded for 35 (92%) patients. For 29 (76%), diagnosis was conducted by molecular study, including 25 (66%) by the national reference mycobacterial laboratory. For 4 patients, diagnosis was confirmed by culture of M. bovis. Osteomyelitis/osteitis for 5 patients was considered BCG related according to pathologic diagnosis o...

most people infected with m .tuberculosis do not develop active disease. in healthy individuals, the lifetime risk of developing infection to disease is 5-10%. reactivation of tb often occurs in older children and adolescent and is more common in patients who acquire tb at age 7 years and older. pulmonary tuberculosis may manifest in several forms, including endobronchial tb with focal lymphade...

A range of different care providers with varying levels of expertise and experience, including primary care staff, general clinicians, and paediatricians, may be involved in managing children with tuberculosis (TB). Clarifying the roles and responsibilities of health care staff for the diagnosis, treatment and prevention of TB in children is important. Roles and responsibilities depend on the r...

We present the case of a 28 year old lady with refractory Crohn's Disease treated with infliximab throughout her pregnancy. Her baby was born healthy and received a Bacillus Calmette-Guérin (BCG) vaccine aged 3 months. Soon after this the infant became unwell and died aged 4.5 months. At post-mortem the cause of death was attributed to an unusual complication of the BCG vaccine, known as dissem...

Dear Editor, Since 1976 Bacillus Calmette-Guerin (an attenuated form of wild type Mycobacterium bovis; BCG) has been extensively used for the treatment of superficial bladder cancer. It is a safe and well tolerated treatment with rare adverse events including allergic reactions, granoulomatous prostitidis or epididymo-orchitis, disseminated infection and BCG sepsis1. Although cystitis is not an...