OBJECTIVE Caveolin-3 (CAV3) protein is known to be expressed specifically in various myocytes, but its physiological function remains unclear. CAV3, located at the cell membrane, may promote the sensitivity of the Akt signaling pathway, which is closely related to glucose metabolism and to cell growth and proliferation. METHODS The CAV3 gene was stably transfected into C2C12 muscle cells, and...

objective: type 2 diabetes mellitus is a complex metabolic disorder with adverse cardiovascular risk. chromium (cr) is an essential nutrient and its role in carbohydrate and lipid metabolism has not been clarified especially in iran. the aim of this study was to evaluate the effect of chromium picolinate administration on blood glucose, hba1c, lipid profile and lipid peroxidation in type 2 diab...

High-fat diets (HFDs) can trigger lipid accumulation, insulin resistance, and inflammatory responses in the body, causing glucose metabolism dysfunction. This study aimed to explore role of nuciferine on HFD-induced disorders obesity mice models, further identify possible underlying mechanisms. In our experiments, effectively ameliorated resistance by IRS/PI3K/AKT pathway, alleviated accumulati...

Regucalcin, which was discovered as a calcium-binding protein in 1978, has been demonstrated to play a multifunctional role as a suppressor in signaling transduction in various types of cells and tissues. Regucalcin has been shown to regulate intracellular calcium homeostasis, protein kinases and phosphatases, nitro oxide production, protein synthesis, gene expression, cell proliferation and ap...

Type I glycogen storage diseases (GSD-I) consist of two major autosomal recessive disorders, GSD-Ia, caused by a reduction glucose-6-phosphatase-α (G6Pase-α or G6PC) activity and GSD-Ib, in the glucose-6-phosphate transporter (G6PT SLC37A4) activity. The G6Pase-α G6PT are functionally co-dependent. Together, G6Pase-α/G6PT complex catalyzes translocation G6P from cytoplasm into endoplasmic retic...

Dietary supplementation with ω-3 polyunsaturated fatty acids (ω-3 PUFAs), specifically the fatty acids docosahexaenoic acid (DHA; 22:6 ω-3) and eicosapentaenoic acid (EPA; 20:5 ω-3), is known to have beneficial health effects including improvements in glucose and lipid homeostasis and modulation of inflammation. To evaluate the efficacy of two different sources of ω-3 PUFAs, we performed gene e...

INTRODUCTION Metabolically obese but normal-weight (MONW) individuals have metabolic features of overt obesity, and abdominal adiposity is common in them. Animal models of MONW individuals are lacking. We aimed to develop an abdominally obese and normal-weight (AONW) rat model. METHODS AND RESULTS Young male Sprague-Dawley rats were fed chow or a modified high-sucrose (HS) diet for 20 weeks. ...