The C-terminal domain (CTD) of Hepatitis B virus (HBV) core protein is involved in regulating multiple stages of the HBV lifecycle. CTD phosphorylation correlates with pregenomic-RNA encapsidation during capsid assembly, reverse transcription, and viral transport, although the mechanisms remain unknown. In vitro, purified HBV core protein (Cp183) binds any RNA and assembles aggressively, indepe...

In the pursuit of materials with structure-related function, directing the assembly of materials is paramount. The resultant structure can be controlled by ordering of reactants, spatial confinement and control over the reaction/crystallisation times and stoichiometries. These conditions can be administered through the use of flow technologies as evidenced by the growing widespread application ...

Chemical circuits can coordinate elaborate sequences of events in cells and tissues, from the self-assembly of biological complexes to the sequence of embryonic development. However, autonomously directing the timing of events in synthetic systems using chemical signals remains challenging. Here we demonstrate that a simple synthetic DNA strand-displacement circuit can release target sequences ...

A simple and general procedure has been developed for the syntheses of ordered largepore (up to 14 nm) mesoporous metal oxides, including TiO2, ZrO2, Nb2O5, Ta2O5, Al2O3, SiO2, SnO2, WO3, HfO2, and mixed oxides SiAlOy, Al2TiOy, ZrTiOy, SiTiOy, ZrW2Oy. Amphiphilic poly(alkylene oxide) block copolymers were used as structure-directing agents in nonaqueous solutions for organizing the network-form...

background: the population of elderly in iran and in the world is increasing. it is predicted that the population of elderly reaches to 10 millions in iran by the year 2019. elderly more than other age groups are at risk of chronic diseases and health problems; and it affects their self-management and makes them feel disabled. since the knowledge of self-management for iranian elderly is not we...

Self-similar groups are a fascinating area of current research. Here we give a short, and hopefully accessible, introduction to them.

Background: Differing perspectives of self-harm may result in a struggle between

The structure of a self-similar group G naturally gives rise to a transformation which assigns to any probability measure μ on G and any word w in the alphabet of the group a new probability measure μ. If μ is a convex combination of μ and the δ-measure at the group identity, then the asymptotic entropy of the random walk (G,μ) vanishes; therefore, the random walk is Liouville and the group G i...

The polyubiquitin signal is post-translationally attached to a large number of proteins, often directing formation of macromolecular complexes resulting in the translocation, assembly or degradation of the attached protein. Recent structural and functional studies reveal general mechanisms by which different architectures and length of the signal are distinguished.