Chemical genetic screening of small-molecule libraries has been a promising strategy for discovering unique and novel therapeutic compounds. However, identifying the targets of lead molecules that arise from these screens has remained a major bottleneck in understanding the mechanism of action of these compounds. Here, we have coupled the screening of a cysteine-reactive fragment-based covalent...

Most knowledge management (KM) projects aim at creating a knowledge base system in which all corporate knowledge is organized according to a single, supposedly shared and objective classification. The underlying assumption is that knowledge can be made objective refining it of all its subjective, contextual, and social aspects. However, a lot of work in disciplines like artificial intelligence,...

This paper introduces a novel splitting criterion parametrized by a scalar ‘α’ to build a class-imbalance resistant ensemble of decision trees. The proposed splitting criterion generalizes information gain in C4.5, and its extended form encompasses Gini(CART) and DKM splitting criteria as well. Each decision tree in the ensemble is based on a different splitting criterion enforced by a distinct...

The aim of this paper is to characterize the notion of aspect in the workspace and in the joint space for parallel manipulators. In opposite to the serial manipulators, the parallel manipulators can admit not only multiple inverse kinematic solutions, but also multiple direct kinematic solutions. The notion of aspect introduced for serial manipulators in [1], and redefined for parallel manipula...

The aim of this paper is to characterize the notion of aspect in the workspace and in the joint space for parallel manipulators. In opposite to the serial manipulators, the parallel manipulators can admit not only multiple inverse kinematic solutions, but also multiple direct kinematic solutions. The notion of aspect introduced for serial manipulators in [1], and redefined for parallel manipula...

1 IRCCyN: UMR CNRS 6596, Ecole Centrale de Nantes, Université de Nantes, Ecole des Mines de Nantes Abstract— Presented in this paper is the kinematic analysis of a symmetrical three-degree-of-freedom planar parallel manipulator. In opposite to serial manipulators, parallel manipulators can admit not only multiple inverse kinematic solutions, but also multiple direct kinematic solutions. This pr...