This study was conducted to evaluate the efficacy of the dipeptide form of phenylalanine as a new source of amino acid in terms of growth performance and whole-body amino acid composition in comparison to the free form for red seabream (Pagrus major). Fish (1.46±0.001 g) were fed four isonitrogenous and isocaloric experimental diets containing 0.7 or 1.4% phenylalanine either in free or dipepti...

The full conformational energy surface is examined for a molecule in which a dipeptide is attached to the same spacer group as another peptide chain, so as to model the seminal steps of β-sheet formation. This surface is compared with the geometrical preferences of the isolated dipeptide to extract the perturbations induced by interactions with the second peptide strand. These interpeptide inte...

Nuclear receptors are key transcription factors that regulate crucial gene networks responsible for cell growth, differentiation, and homeostasis. Nuclear receptors form a superfamily of phylogenetically related proteins and control functions associated with major diseases (e.g. diabetes, osteoporosis, and cancer). In this study, a novel method has been developed for classifying the subfamilies...

BACKGROUND Gene therapy is most effective when delivery is both efficient and safe. However, it has often proven difficult to find a balance between efficiency and safety in case of viral or polymeric vectors for gene therapy. Peptide based delivery systems may be attractive alternatives but their relative instability to proteolysis is a major concern in realizing their potential application in...

The survival of species depends on the fertility organisms. It is also worthwhile to study proteins that can regulate reproductive activity Since biological experiments are laborious confirm proteins, it has become a priority develop relevant computational models predict function fertility-related proteins. With development machine learning, pertinent various algorithms be key identifying In th...

A lysine auxotroph of Escherichia coli W can use lysine oligopeptides as a source of the required amino acid. A mutant, defective in oligopeptide transport, was isolated from this strain with the use of resistance to the bactericidal action of triornithine as a selection procedure. The triornithine-resistant mutant could no longer grow upon lysine oligopeptides. In an analogous manner a triorni...