PURPOSE To research the acid-triggered core cross-linked folate-poly(ethylene glycol)-b-poly[N-(N',N'-diisopropylaminoethyl) glutamine] (folated-PEG-P[GA-DIP]) amphiphilic block copolymer for targeted drug delivery and magnetic resonance imaging (MRI) in liver cancer cells. METHODS As an appropriate receptor of protons, the N,N-diisopropyl tertiary amine group (DIP) was chosen to conjugate wi...

Background Drug-induced parkinsonism (DIP) is the most common movement disorder induced by antipsychotics. Although DIP is mostly symmetric, asymmetric DIP is reported in a substantial part of the patients. We investigated the frequency of motor asymmetry in DIP and its relationship to the severity of psychopathology in long-stay psychiatric patients. Methods We obtained data from a cohort st...

OBJECTIVES To derive a method for retrospectively estimating cumulative exposure to organophosphate (OP) pesticides among a cross section of United Kingdom sheep dippers, as part of a wider epidemiological study of neurological abnormality within this group of workers. METHODS A hygiene study of dipping sessions at 20 farms using diazinon based dips was carried out by two experienced occupati...

The enzyme dipeptidase-A (DIP-A) in Drosophila melanogaster is coded by a second chromosome locus that is polymorphic for three allozymes in natural populations. DIP-A appears to be the only enzyme in D. melanogaster capable of hydrolyzing the dipeptide glycyl-L-isoleucine, since flies homozygous for null alleles at this locus have no detectable glycyl-L-isoleucine-ase activity. DIP-A activity ...

The method of Computing simultaneously and objectively numerous descriptive dip-parameters from digitized cardiotocograms (CTG) de'scribed in Part I, allows a closer investigation of the content of clinical Information of single dipparameters. This work focuses on the following questions: 1. How do various dip-parameters behave in the cardiotocograms of normal newborns and of asphyxiated newbor...

Seven ruminally and duodenally cannulated steers (264 +/- 8 kg BW) consuming low-quality forage (5% CP; 61% NDF; 31% ADF) were used to determine the influence of CP degradability and supplementation frequency (SF) on ruminal fermentation characteristics. Treatments included an unsupplemented control and degradable intake protein (DIP) or undegradable intake protein (UIP) provided daily, every 3...

Chen Phoon Ping, MBBS, FANZCA, FFPMANZCA, FHKCA, FHKAM, Dip Pain Mgt; Josephine WY Ip, MBBS, MS, FRCS (Ed), FHKAM (Ortho), Dip Hand Surg (FESSH); Joseph MK Lam, MBChB, FRCS (Edin), FCSHK, FHKAM (Surg); Vincent Mok, MBBS, FHKAM (Med), FRCP (Edin), MD (CUHK); Tsoi Tak Hong, MBBS, MRCP, FRCP (Edin), FRCP (Glas), FHKCP, FHKAM (Med); Wong Chun Por, MBBS, FHKAM (Med), FRCP (Lond), FRCP (Glas), FHKCP;...

The Multidisciplinary Panel on Neuropathic Pain Chen Phoon Ping, MBBS, FANZCA, FFPMANZCA, FHKCA, FHKAM, Dip Pain Mgt; Josephine WY Ip, MBBS, MS, FRCS (Ed), FHKAM (Ortho), Dip Hand Surg (FESSH); Joseph MK Lam, MBChB, FRCS (Edin), FCSHK, FHKAM (Surg); Vincent Mok, MBBS, FHKAM (Med), FRCP (Edin), MD (CUHK); Tsoi Tak Hong, MBBS, MRCP, FRCP (Edin), FRCP (Glas), FHKCP, FHKAM (Med); Wong Chun Por, MBB...

Exploration of a new differentiation therapy that extends the range of differentiation for treating acute myeloid leukemia (AML) is attractive to researchers and clinicians. Here we report that diptoindonesin G (Dip G), a natural resveratrol aneuploid, exerts antiproliferative activity by inducing G2/M phase arrest and cell differentiation in AML cell lines and primary AML cells. Gene-profiling...