Reaction of the known titanocene Y 2 with methyl lithium at -15 degrees C yields bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dimethyl (dimethyl titanocene Y, 3), a hitherto unknown, surprisingly robust titanium (IV) dimethyl species. Dimethyl titanocene Y was utilized in the preparation of several bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dicarboxylates by the reaction with th...

mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

so42-/zno-tio2 catalyst was prepared by sulfating zno-tio2 powders with h2so4 solution. the catalyst was characterized by xrd, ir and hammett indicator. the catalyst showed strong acidity(h0 ≦-16.0). the optimum conditions are found that the calcination temperature is 823k and the soaked consistency of h2so4 is 1 mol/dm3. then so42-/zno-tio2 was applied as the catalyst in the catalytic synthesi...

background: the memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (stz) in rats through activation of oxidative stress, is accepted as sporadic alzheimer’s disease (ad) model in most experimental studies. dimethyl sulfoxide (dmso) as a solvent is widely used in animal studies to have antioxidant effects as well. however, no report is available about dm...

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Abstract Background Vegetables and rice produced in Cuba may contain residue of pesticides that exceed the maximum limits (MRLs). Pesticide residues on crop samples from Sancti Spíritus province were analyzed. Based these data, a risk assessment consumer exposure was conducted. Methods Samples collected during 2017, 2018, 2019 periods analyzed using UPLC-MS/MS GC/ECD chromatography techniques. ...

The synthesis of series of tripodal ligands: N,N-bis((3-carboxyethyl-5-dimethyl-1H-pyrazol-1yl)methyl)phenylamine L1, N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)phenylamine L2, N,N-bis((3carboxyethyl-5-dimethyl-1H-pyrazol-1-yl)methyl)pyridin-2-ylamine L3, N,N-bis((3,5-dimethyl-1H-pyrazol1-yl)methyl)pyridin-2-amine L4, N,N-bis((3-carboxyethyl-5-dimethyl-1H-pyrazol-1-yl)methyl)-2nitrophenylamin...

Dimethyl-celecoxib is a celecoxib analog that lacks the capacity as cyclo-oxygenase-2 inhibitor and therefore the life-threatening effects but retains the antineoplastic properties. The action mechanism at the molecular level is unclear. Our in vitro assays using a sarcoplasmic reticulum preparation from rabbit skeletal muscle demonstrate that dimethyl-celecoxib inhibits Ca2+-ATPase activity an...

the interaction between propranolol (prop) and human serum albumin (hsa) was studied in the presence of dimethyl methylphosphonate (dmmp). dmmp is usually considered as a simulant for chemical warfare agents (cwas). for this purpose fluorescence quenching, resonance light scattering (rls), synchronous, three-dimensional fluorescence spectroscopy and molecular dynamics (md) simulation were emplo...

Pure and mixed cultures of Methylophaga sulfidovorans and Thiobacillus thioparus T5 were grown in continuous cultures on either dimethyl sulfide, dimethyl sulfide and H(inf2)S, or H(inf2)S and methanol. In pure cultures, M. sulfidovorans showed a lower affinity for sulfide than T. thioparus T5. Mixed cultures, grown on dimethyl sulfide, showed coexistence of both species. M. sulfidovorans fully...