Methylene blue (MB) is a cationic thiazine dye with the chemical name tetramethylthionine chloride. It has a characteristic deep blue color in the oxidized state, but the reduced form, leukomethylene blue (LMB), is colorless. Methylene blue has been widely used in a variety of clinical settings to identify anatomic (Manhes et al., ’94; Sills and Zinkham, ’94; Barber et al., ’95) and pathologic ...

Objective To examine if methylene blue (MB) can counteract or prevent protamine (P) cardiovascular effects. Methods The protocol included five heparinized pig groups: Group Sham -without any drug; Group MB - MB 3 mg/kg infusion; Group P - protamine; Group P/MB - MB after protamine; Group MB/P - MB before protamine. Nitric oxide levels were obtained by the nitric oxide/ozone chemiluminescence ...

the nano sized tio2 and zno are the most active photocatalysts.  methylene blue was used as a reference molecule for the photocatalytic degradation. the tio2 and zno can totally remove methylene blue dye. the effect of various process parameters like initial concentration, contact time, dose of catalyst and ph on the extent of removal of dye by photocatalysis in presence of tio2 and zno was stu...

this paper deals with application of polyaniline coated on wood sawdust for removal ofmethylene blue (mb) dye from aqueous solutions. polyaniline coated onto sawdust (termedas pan/sd) was prepared via direct chemical polymerization onto sawdust which waspreviously soaked in the monomer (aniline) solution in acidic (hc1) media. adsorptionexperiments were carried out using batch system. the effec...

background:organophosphates are commercially available agrochemicals for pest control, but may be abused for deliberate self-poisoning. we report a case of suicidal ingestion of dimethoate, a moderately toxic organophosphate insecticide, which can cause refractory hemodynamic instability, and the successful use of methylene blue (mb) for counteracting this complication. case presentation: an un...

in the present study, comparison of  photocatalytic activity of nanostructures semiconductor zinc oxide (zno) was prepared using the different methods on the degradation of organic dye such as methylene blue that was investigated. previous studies have proved that such semiconductors can degrade most kinds of persistent organic pollutants, such as detergents, dyes, pesticides and volatile organ...

The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by t...

1. Methylene blue has no catalytic effect on the oxygen consumption of those normal adult tissues which do not possess aerobic glycolysis. The dye increases the oxygen consumption of these tissues when their respiration has been inhibited by the addition of KCN and their fermentative power thus brought into action. 2. Methylene blue increases the oxygen consumption of normal tissues having aero...

Seventeen commonly used dyes and 16 of their metabolites or derivatives were tested in the Salmonella-mammalian microsome mutagenicity test. Mutagens active with and without added Aroclor-induced rat liver microsome preparations (S9) were 3-aminopyrene, lithol red, methylene blue (USP), methyl yellow, neutral red, and phenol red. Those mutagenic only with S9 activation were 4-aminopyrazolone, 2...

Methylene blue is a phenothiazine-related heterocyclic aromatic molecule presently used in the treatment of methemoglobinemia. Recently, it has been implicated in the treatment of severe refractory vasoplegic shock caused by anaphylaxis, sepsis, or postcardiopulmonary bypass. We present a case of a 27-year-old male with profound vasoplegic shock of unknown etiology which was refractory to vasop...