Virtual screening has been widely used in the drug discovery process. Ligand-based virtual screening (LBVS) methods compare a library of compounds with a known active ligand. Two notable advantages of LBVS methods are that they do not require structural information of a target receptor and that they are faster than structure-based methods. LBVS methods can be classified based on the complexity ...

One new coordination polymer, namely, [Cd3(H2L)3(Pza)2(H2O)2]n (1) was synthesized by the reaction of Cd(NO3)2·4H2O with 1,4-di(1H-imidazol-4-yl)benzene (H2L) and 3,5-pyrazoledicarboxylic acid (H3pza) and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis, and powder X-ray diffraction (PXRD). The H3pza ligand was completely deprotonated to pza3−, which bridge...

Zirconium trisulphide (ZrS3), a member of the layered transition metal trichalcogenides (TMTCs) family, has been studied by angle-resolved photoluminescence spectroscopy (ARPLS). The synthesized ZrS3 layers possess a pseudo one-dimensional nature where each layer consists of ZrS3 chains extending along the b-lattice direction. Our results show that the optical properties of few-layered ZrS3 are...

This paper introduces the energy compaction efficiency of a novel two-dimensional (2D) representation for compression of recorded power uality event data. The 2D representation enables to exploit redundancy across vertical samples that correspond to samples which are far from ach other in time. In one-dimension (1D), compression algorithms are unable to depict the correlation between such far a...

Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of anisotropic nano-objects (one-dimensional (1D) nanotubes, nanowires, or two-d...

In our screening of marine Streptomycetes for bioactive compounds, in addition to the known metabolites rabelomycin (1), fridamycin D (2b), N-benzylacetamide and N-(2'-phenylethyl)acetamide, two new anthracycline antibiotics designated as himalomycin A (2c) and B (2d) were isolated from the culture broth of the marine Streptomyces sp. isolate B6921. The structure of the new antibiotics was dete...

Hidden Markov models are widely applying in data classification. They are using in many areas where 1D data are processing. In the case of 2D data, appear some problems with applying 2D HMM. This paper describe the important limitations of HMM when we have to processing two dimensional data.

Submit Manuscript | http://medcraveonline.com Abbreviations: 1D: One-Dimensional; 2D: Two-Dimensional; 3D: Three-Dimensional; DGTD: Discontinuous Galerkin TimeDomain; FEs: Finite Elements; TM: Transverse Magnetic; TE: Transverse Electric; ODE: Ordinary Differential Equations; LSERK: Low-Storage Explicit Runge-Kutta; CFL: Courant-Friedrichs-Levy; TD: Time-Domain; PEC: Perfect Electric Conductor;...

In the pursuit of high injection current diode nanodevices, entire one-dimensional (1D) ZnO coaxial nanostructures with p-n homojunctions is one of the ideal structures. In this study, we synthesized entire 1D ZnO-based coaxial homojunction diodes with p-type Ag-doped ZnO (SZO) nanostructure shells covering n-type Ga-doped ZnO (GZO) nanopagoda (NPG) cores by a metal-organic chemical vapor depos...

DNA origami is an emerging technology for designing defined two- and three-dimensional (2D and 3D) DNA nanostructures. Here, we report an introductory practical guide with step-by-step experimental details for the design and synthesis of origami structures, and their size expansion in 1D and 2D space by means of self-assembly.