Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%. At constant heart rates, pretreatment with diphenylhydantoin sodium did not alter the elevation of rate of rise of left ventricular pressure produced by the glycoside. Two implications have been drawn from these findings. First, the inotropic and arrhythmic act...

A study, which arose out of a general-practitioner teaching programme in clinical pharmacology, was designed to assess the use of digitalis in 391 patients in general practice. Clinical, biochemical, and pharmacological data were used to assess whether digitalis treatment should be discontinued (89 patients; 22.8%); the dose kept unchanged (47; 12%); or the dose increased (47; 12%) or decreased...

OBJECTIVE The authors sought to derive heritability estimates for anorexia nervosa and to explore the etiology of the comorbid relationship between anorexia nervosa and major depression. METHOD They applied bivariate structural equation modeling to a broad definition of anorexia nervosa and lifetime major depression as assessed in a population-based sample of 2,163 female twins. RESULTS Ano...

anorexia nervosa (an) is a serious psychiatric illness marked by an inability to maintain a normal healthy body weight. the prevalence of an comorbid with other psychiatric disorders has been reported to be quite high. whereas depression and anxiety disorders are the most common comorbid diagnoses in anorexic patients, the dual-diagnosis of anorexia and schizophrenia is a relatively rare condit...

Patients with chronic renal failure develop a cardiomyopathy characterized by marked diastolic dysfunction and left ventricular hypertrophy. Interestingly, they also have substantial increases in the circulating concentrations of digitalis like substances. Digitalis like substances produce reactive oxygen species as part of the signal cascade induced by binding to the sodium pump and patients, ...

To assess the possible role of digitalis in the etiology of arrhythmia following cardiopulmonary bypass, serum digoxin or digitoxin was determined serially by radioimmunoassay in 24 chronically digitalized patients undergoing open-heart surgery. After an initial fall during bypass probably secondary to intraoperative fluid, serum digitalis rebounded, rising to or surpassing the preoperative val...

Serial autocorrelation functions and histograms of R-R intervals in patients with atrial fibrillation, with and without digitalis, at rest and during exercise, were produced by a computer. At rest with and without digitalis the first and higher order coefficients did not differ from zero. During exercise (also with and without digitalis) only the first autocorrelation coefficient became slightl...

T HERE HAS BEEN considerable interest in whether or not changes in the thyroid state modify the effectiveness of digitalis. A number of reports have suggested that patients with hyperthyroidism associated with congestive heart failure or atrial fibrillation are relatively unresponsive to the usual doses of digitalis.1-8 Others have indicated, however , that these patients may respond to the ord...

Amongst a series of cases of partial heart block, collected over a period of years, there were some in which treatment with digitalis was mainly or partly responsible. This group involves some special problems that seem worth separate consideration. The slow pulse, even as slow as 35 in a minute, after the administration of digitalis was one of the original observations of Withering (1785). Muc...