We analyzed the expression levels of fluoropyrimidine-metabolizing enzymes (thymidylate synthase [TS], dihydropyrimidine dehydrogenase [DPD], thymidine phosphorylase [TP] and orotate phosphoribosyltransferase [OPRT]) to identify potential biomarkers related to treatment outcomes in gastric cancer (GC) patients receiving adjuvant S-1 chemotherapy. In this study, 184 patients who received curativ...

BACKGROUND Deoxypyridinoline (Dpd) is one of the two pyridinium cross-links that provide structural rigidity to type I collagen in bone. During osteoclastic resorption, Dpd is released into circulation and is excreted in the urine in free and peptide-bound forms. Free and total Dpd are highly correlated, but whether the free-to-total cross-link ratio is constant in both normal and high bone tur...

Thymidylate synthase (TS) is essential in thymidylate biosynthesis and DNA replication. Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in pyrimidine catabolism and is important in catabolism of 5-fluorouracil (5-FU). The significance of TS and DPD expressed in lung cancer remains controversial. Here we analyzed the relationship between TS and DPD expression and clinicopathologi...

ACI = Adjacent Channel Interferences APSK = Amplitude Phase Shift Key BER = Bit Error Rate DPD = Digital Predistortion DTH = Direct To Home EQ = EQualization FIR = Finite Impulse Response GW = Gate Way HPA = High Power Amplifier IBO = Input Back-Off IMUX = Input ISI = Inter-Symbol Interference L-TWTA = Linearized Travelling Wave Tube Amplifier LS = Least Squares OBO = Output Back-Off OMUX = Out...

This work combines the advantages of two different RF power amplifier (PA) linearization techniques: digital predistortion (DPD) and Cartesian feedback (CFB). Cartesian feedback, an extension of classical continuoustime feedback, is limited by the bandwidth of its loop transfer function; this bandwidth, in turn, puts an upper limit on the bandwidth of the data input. However, this limitation gi...

At present, fluoropyrimidine, based on 5-fluorouracil (5-FU), remains one of the most frequently prescribed chemotherapeutics drugs for the treatment of cancer. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the catabolism of 5-FU, and DPD enzymatic activities are usually varied dramatically from individual to individual, including both the intrapatient differences and the...

The nonlinearity of the fifth-generation (5G) millimeter-wave (mmWave) phased array transmitter (TX) depends on variations in beamforming coefficients, e.g., due to unwanted amplitude errors phase shifters or purposely introduced shape beam, as well other analog component variations. Therefore, also digital predistortion (DPD) coefficients depend and require a continuous update for different be...

Switched capacitor power amplifiers (SCPAs) are a class of digital transmitters which have shown promising results for high linearity with good DE. Their is limited by AM-PM distortion, caused difference in output conductance switching and non-switching driver cells. Often, DPD required to transmit higher order modulation schemes. In this letter, cell implementation as an inverter drain resisto...

Dihydropyrimidine dehydrogenase (DPD) is the initial key enzyme in 5-fluorouracil (5-FU) catabolism. We measured DPD activities represented as DPD protein levels (units/mg protein) and the associated mRNA levels in tumorous and normal tissues from 40 colorectal cancer patients, and we studied the relation to 5-FU concentrations in the same samples after treatment with doxifluridine, a prodrug o...

1. The oxidation of NN-dimethyl-p-phenylenediamine (DPD) by inorganic oxidants and by caeruloplasmin was studied. Some experiments were also made with NNN'N'-tetramethyl-p-phenylenediamine (TPD). 2. E(mM) (550) of the first free radical oxidation product of DPD (DPD(+)) was 9.8 and E(mM) (563) of the corresponding product of TPD (TPD(+)) was 12.5. 3. The non-enzymic decomposition of DPD(+) was ...