One of the goals of medicinal chemistry research and drug discovery is to provide a rationalbasis for the design of new medicinal agents. Organic compounds and their reactions have beenutilized by people since antiquity. Due to the increasing demand for bioactive molecules, organicchemists are increasingly required to synthesize new compounds of biological interest. AsBenzimidazoles are very us...

NATIONAL INSTITUTES OF HEALTH Cigarette smoking causes a variety of lifethreatening diseases, including lung cancer, emphysema, and heart disease. An estimated 400,000 deaths each year are caused directly by cigarette smoking. Smoking is responsible for changes in all parts of the body, including the digestive system. This fact can have serious consequences because it is the digestive system th...

Obesity is a growing medical and public health problem worldwide. Many digestive diseases are related to obesity. In this article, the current state of our knowledge of obesity-related digestive diseases, their pathogenesis, and the medical and metabolic consequences of weight reduction are discussed. Obesity-related digestive diseases include gastroesophageal reflux disease, Barrett's esophagu...

BACKGROUND In recent years, especially after the development of sophisticated metagenomic studies, research on the intestinal microbiota has increased, radically transforming our knowledge about the microbiome and its association with health maintenance and disease development in humans. Increasing evidence has shown that a permanent alteration in microbiota composition or function (dysbiosis) ...

This article discussed the diagnosis and management of acute GI bleeding, prophylaxis against GI bleeding, acute pancreatitis, and acalculous cholecystitis. These diseases are commonly encountered in the ICU setting. Acute GI bleeding is usually obvious and with GI and with available interventional radiologic techniques, patients rarely need surgery. Conversely, acalculous cholecystitis is diff...

BACKGROUND The aim of the present study was to provide a broad picture of the morbidity among employees in the Danish hotel and restaurant industry. METHODS Cohorts of all 20-59-year-old employees in the Danish hotel and restaurant industry in the years 1981, 1986, 1991 and 1994 were formed to calculate age-standardized hospitalization ratios (SHR) and time trends (1981-1997) for many differe...

considering the structure of appendix,its great blood supply and lymphatic tissue,and its anatomical location it seems to have an immunologic role.there are no clear studies regarding the relation between appendectomy and cancer of digestive system.therefore,this stuty proposed for to clarify the relation between previous appendectomy and present gastrointestinal (GI)adenocarcinoma.the cancer g...

BACKGROUND Aberrant expression of defensins is implicated in the pathogenesis of digestive diseases. However, the contribution of specific defensins and the influence of their genetic polymorphisms on the progression of digestive diseases remain controversial. In the present meta-analysis, we investigated the association between DEFB1 SNPs and the susceptibility to digestive diseases. MATERIA...