Digestive tract damage during graft-versus-host reaction (GVHR) causes high morbidity and mortality. Diagnosis is often late because biopsies are performed when clinical signs are severe and pathologic markers of early inflammatory lesions are lacking. Eosinophils are inflammatory cells, cytotoxic in vitro to digestive epithelium; they are found in biopsy specimens taken during acute flare-ups ...

Gastrointestinal symptoms occurring in patients with Crohn's disease (CD) can be related to disease activity or to intercurrent infection. Absence of appropriate stool work-up can lead to misdiagnosis and wrong treatment. We report here two cases of acute cryptosporidiosis in patients with CD. This microorganism can trigger IBD flare or cause severe infections in immunocompromised host. Adding ...

In this article I will argue that we are witnessing at this moment the third wave of biological psychiatry. This framework conceptualizes mental disorders as brain disorders of a special kind that requires a multilevel approach ranging from genes to psychosocial mechanisms. In contrast to earlier biological psychiatry approaches, the mental plays a more prominent role in the third wave. This wi...

This report summarizes what we believe to be the first verifiable case of a significant and progressive motor neuron disease (MND) consistent with amyotrophic lateral sclerosis that resolved during treatment with i.v. ceftriaxone plus oral atovaquone and mefloquine. The rationale for use of these antibiotics was (i) positive testing for Borrelia burgdorferi and (ii) red blood cell ring forms co...

Malignant bone tumors in children occur rarely. Estimated annual incidence is 7 cases per 1.000.000 children under the age of 16. Due to its rare occurrence and often unspecific signs and symptoms, a lot of physicians do not consider this diagnosis early enough. Therefore it is not surprising that the majority of patients are referred to the pediatric oncologist when the disease is already in a...

Heart failure is common in the elderly and is associated with a significant morbidity and mortality. It accounts for about 5% of adult medical admissions and the expenditure of 1% of the total National Health Service budget. Clinical presentation in old age may be with the classical symptoms of heart failure but often, due to multiple pathology and low functional ability, presentation is atypic...

OBJECTIVES To evaluate the effect of obstructive sleep apnea (OSA) surgery on long-term (5-year) subjective outcomes, including sleep disordered breathing (SDB) symptoms and other complications, in patients with OSA. METHODS We enrolled patients who underwent diagnostic polysomnography for OSA between January 2006 and December 2006 in ten hospitals. Patients either were treated for OSA or wer...

Intestinal intussusception is a common problem in the children, but in adults, it's very unusual. It's responsible for 1-2% of the intestinal obstruction in adults. Adult intussusception etiology differs from that in pediatric patients. Almost all of such cases are due to organic lesions in the adult. Patients commonly presents with nonspecific signs and symptoms similar to a bowel obstruction....

Disaccharide intolerance has been described in cystic fibrosis of the pancreas (Cozetto, 1963; Nordio et al., 1966; Sunshine and Kretchmer, 1964). However, the relation between clinical signs and symptoms, and biochemical investigations is not clear. For instance, Cozetto (1963) reported isolated depressed lactase activity in an otherwise normal mucosa, but gave no clear clinical evidence in su...

OBJECTIVE To analyze the clinical characteristics of inpatients with anaphylaxis and the factors that influenced those characteristics. METHODS Using the patient records from 1990 to 2013 from three highly ranked Chinese hospitals, we retrospectively analyzed the characteristics of 108 inpatients with anaphylaxis (not anaphylaxis admitted). RESULTS The mean patient age was 42 ± 20 years old...