نتایج جستجو برای: dicrotic notch
تعداد نتایج: 18862 فیلتر نتایج به سال:
In this research, rotating bending fatigue test at minimum to maximum stress ratio of R=-1 was used for investigating the fatigue behavior of Ti-6Al-4V alloy. Both smooth and notched specimens, with elastic concentration factor, kt, of approximately 3.6 and 4.1 were used for this purpose.In addition, the effect of variation in ultimate tensile strength, UTS, on the fatigue behavior of this allo...
1. Abstract 2. Introduction 3. Notch signaling pathway 3.1. Notch receptors and ligands 3.2. Notch signaling activation 3.3. Notch signaling targets 4. Notch signaling in tumorigenesis 4.1. Cell proliferation 4.2. Cell survival (apoptosis evasion) 4.3. Angiogenesis 4.4. Cell invasion and metastasis 4.5. Notch and viral oncogenes 4.5.1. EBV viral protein EBNA2 and Notch 4.5.2. HPV viral protein ...
The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and ch...
This study investigated the roles of Notch‑1 in colorectal carcinoma, to assess the mechanisms. The expression of Notch‑1 and its ligand-Jagged1 was detected in human colorectal carcinoma, colorectal adenoma, paracancerous tissue and normal colorectal tissue by immunohistochemistry. Colorectal carcinoma cell lines were utilized to confirm the expression of Notch‑1 in colorectal carcinoma cells....
Notch signal transduction is mediated by proteolysis of the receptor and translocation of the intracellular domain (IC) into the nucleus, where it functions as a regulator of HES gene expression after binding to the DNA-binding protein RBP-J kappa. The mammalian Notch receptors are structurally very similar, but have distinct functions. Most notably, Notch 1 IC is a potent activator of the HES ...
Genetic and phenotypic analysis of strawberry notch suggests that its gene product is required during embryogenesis and oogenesis, and for the development of the eye, wing and leg. Several lines of evidence suggest that strawberry notch participates together with Notch in many common pathways. A number of strawberry notch mutant phenotypes are similar to those of Notch mutants and can be rescue...
Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity. Here we provide evidence for Notch regulation at an earlier step - mRNA 3' processing. Processing at the Notch consensus polyadenylation site appears by default to be suppressed in Drosophila embryos. Interference w...
Abnormalities have been noted in the arterial pulse wave of human subjects with peripheral arteriosclerosis and with hypertension. The major change, diminution to disappearance of the dicrotic wave, has also been found in young diabetic subjects. The present study reports on the differences in the configuration of the arterial pulse wave of 162 diabetic subjects between the ages of 11 and 29 ye...
On the basis of observations of arterial pulse forms in anesthetized dogs, a hypothesis is developed to account for the genesis of the aortic standing wave which is responsible for the dicrotic characteristics of pulses recorded from the abdominal-femoral system. A sudden lowering of resistance to pulse wave propagation in the region of the diaphragm and an increase in resistance in the periphe...
BACKGROUND Lung cancers are resistant to conventional chemotherapeutic interventions such as paclitaxel. Notch signaling is crucial in the chemoresistance of lung cancer cells. The Notch inhibitor gamma-secretase inhibitor (GSI) inhibits the Notch signaling pathway. MATERIAL AND METHODS Here, we evaluated how Notch-3 inhibition by GSI can enhance the sensitivity of lung cancer cells to paclitax...
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