The results of several large studies of hypertension and follow up studies on insured people have indicated that the lower the blood pressure the better for longevity. These studies excluded subjects with overt ischaemia. More recently long term studies of hypertension that included patients with more severe forms of hypertension and did not exclude those with overt ischaemia have shown a J sha...

A link between prenatal malnutrition and hypertension in human populations has recently been proposed. Rat models of prenatal malnutrition have provided major support for this theory on the basis of tail-cuff measurements. However, this technique requires restraint and elevated temperature, both potential sources of stress. To determine the effect of prenatal protein malnutrition on blood press...

Stable junctional rhythm was induced in 14 of 25 anesthetized dogs by exclusion of the sinus node and surrounding atrial tissue. In 12 of the 14 dogs diastolic slope was recorded through a unipolar lead consisting of a terminal of a plunge or catheter electrode placed in the His bundle area coupled with an indifferent superior vena caval electrode. Reversed polarity, high-gain amplification (0....

Background A 3D Dual Cardiac Phase (3D-DCP) scan was proposed to obtain systolic and diastolic images with equivalent quality and scan time compared to the 3D single cardiac phase acquisition (Uribe et al, Radiology 2008). In this work, we propose to accelerate the acquisition and reconstruction of the 3D-DCP approach by sharing information from the outer k-space of both cardiac phases using Ra...

PURPOSE Aim of the study was to investigate diagnostic accuracy of cardiac computed tomography angiography (CCTA) between left ventricular end-systolic (LVES) and left ventricular end-diastolic (LVED) cardiac phase for thrombus detection in patient's prior to pulmonary vein isolation (PVI). MATERIALS AND METHODS 182 consecutive Patients with drug refractory AF scheduled for PVI (62.6% male, m...

Parker, Kevin Kit, James A. Lavelle, L. Katherine Taylor, Zifa Wang, and David E. Hansen. Stretch-induced ventricular arrhythmias during acute ischemia and reperfusion. J Appl Physiol 97: 377–383, 2004; 10.1152/japplphysiol.01235.2001.—Mechanical stretch has been demonstrated to have electrophysiological effects on cardiac muscle, including alteration of the probability of excitation, alteratio...

BACKGROUND Previous studies have reported an important role for right ventricular function in the pathophysiology of the low cardiac output state that can accompany right ventricular infarction. Some studies have suggested that right ventricular distensibility impairs right ventricular filling and stroke output; others have demonstrated that the pericardium can mediate depressed left ventricula...

Background: Diastolic retrograde flow in the descending aorta has been associated to the severity of aortic regurgitation; however, most of the parameters related to flow velocity are not validated with a reference imaging technique. Objective: The aim of this study was to assess the usefulness of diastolic retrograde flow in the descending thoracic aorta and the abdominal aorta in the quantifi...

Mechanical stretch has been demonstrated to have electrophysiological effects on cardiac muscle, including alteration of the probability of excitation, alteration of the action potential waveform, and stretch-induced arrhythmia (SIA). We demonstrate that regional ventricular ischemia due to coronary artery occlusion increases arrhythmogenic effects of transient diastolic stretch, whereas global...

Data acquisition for phase contrast velocity mapping of myocardial motion is typically based on multiple breath-held 2D measurements with limited acquisition duration and consequently relatively poor temporal resolution. In order to overcome the limitations of breath-hold acquisitions, an improved navigator-guided technique was implemented based on 2 navigator signals within each cardiac cycle ...