The efficient asymmetric hydrosilylation of imines in the presence of polymethylhydrosiloxane has been investigated by screening chiral diamine-zinc complexes. A series of chiral diamine ligands were prepared from optically pure 1,2-diphenyl-1,2-ethanediamine and screened for effectiveness. N-Benzylic substituents were required for high enantioselectivity; ligands with bulky groups or extra coo...

Total synthesis of spider toxins HO-416b (1) and Agel-489 (2) was accomplished using the 2-nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. In this strategy, the C-N bonds were constructed by alkylation of sulfonamides with alkyl halides or Mitsunobu reaction with the corresponding alcohol. Beginning with monoprotection of the symmetrical diamine, the construction o...

In the title compound, [CuCl(2)(C(27)H(32)N(2))], which bears a chiral diamine ligand, viz (R,R)-N,N,N''- tribenzyl-cyclo-hexane-1,2-diamine, the Cu(II) ion is ligated by two N and two Cl atoms in a distorted square-planar geometry. The coordination of the ligands to the Cu(II) ion results in the formation of a five-membered heterocyclic ring and a chiral center at the monosubstituted nitro-gen...

The mol-ecule of the title pyridine derivative, C(5)H(7)N(3), shows approximately non-crystallographic C(s) symmetry. Intra-cyclic angles cover the range 117.50 (14)-123.03 (15)°. In the crystal, N-H⋯N hydrogen bonds connect mol-ecules into a three-dimensional network. The closest inter-centroid distance between two π-systems occurs with the c-axis repeat at 3.9064 (12) Å.

The mol-ecule of the title compound, C(6)H(7)N(3)O(2), a derivative of o-phenyl-enediamine, nearly shows non-crystallographic C(s) symmetry. C-C-C angles span the range 116.25 (11)-122.35 (11)°. In the crystal, inter-molecular N-H⋯O and N-H⋯N hydrogen bonds connect mol-ecules into undulating sheets perpendicular to the crystallographic a axis. A weak intra-molecular N-H⋯O hydrogen bond is also ...

In the title mol-ecule, C5H7N3, intra-cyclic angles cover the range 117.15 (10)-124.03 (11)°. The N atoms of the amino groups have trigonal-pyramidal configurations deviating slightly from the pyridine plane by 0.106 (2) and -0.042 (2) Å. In the crystal, the pyridine N atom serves as an acceptor of an N-H⋯N hydrogen bond which links two mol-ecules into a centrosymmetric dimer. Inter-molecular N...

[structure: see text] We synthesized estrone oximes as chemical inducers of protein heterodimerization (CIDs). Estrone-17-(O-carboxymethyl)oxime coupled to biotinamidocaproic acid via N,N'-dimethylhexane-1,6-diamine efficiently heterodimerizes estrogen receptors (ERs) and streptavidin Y43A in yeast three hybrid systems, activating gene expression over 100-fold at 10 microM. Related hexane-1,6-d...

The asymmetric unit of the title compound, C(30)H(28)N(2)O(2), comprises half of a potential tetra-dentate Schiff base ligand; an inversion centre is situtated at the center of the butane-diamine spacer. The central methyl-ene segment of the diamine spacer is disordered over two positions with a refined site-occupancy ratio of 0.651 (7):0.349 (7). The phenyl ring and the hy-droxy-substituted be...