BACKGROUND COPD will become the third leading cause of death by 2020. There are many situations in which spirometry, the primary tool for diagnosis of COPD, cannot be performed, and thus, the staging and status of these patients cannot be determined. To date, there is no known biochemical marker used for diagnosing COPD. This study aimed to explore the utility of biomarkers for diagnosis of COP...

Prostate cancer is the most frequently diagnosed malignancy in American men, and a more aggressive form of the disease is particularly prevalent among African Americans. The therapeutic success rate for prostate cancer can be tremendously improved if the disease is diagnosed early. Thus, a successful therapy for this disease depends heavily on the clinical indicators (biomarkers) for early dete...

Hepatocellular carcinoma (HCC) is one of the most common human malignancies. Therefore, developing the early, high-sensitivity diagnostic biomarkers to prevent HCC is urgently needed. Serum a-fetoprotein (AFP), the clinical biomarker in current use, is elevated in only ~60% of patients with HCC; therefore, identification of additional biomarkers is expected to have a significant impact on publi...

Prostate cancer (PCa) has become to have the highest incidence and the second mortality rate in western countries, affecting men's health to a large extent. Although prostate-specific antigen (PSA) was discovered to help diagnose the cancer in an early stage for decades, its specificity is relative low, resulting in unnecessary biopsy for healthy people and over-treatment for patients. Thus, it...

Considering the high mortality rates and the unfavorable prognosis of gastric cancer (GC) as well as the lack of a clinical predictive marker, which is sufficiently sensitive to GC, it is of great significance to investigate new sensitive and specific markers for GC diagnosis. MicroRNAs (miRNAs) could be a practical form of potential biomarkers in the diagnosis of human disease, and they are co...

1Unit of Molecular Biology and Viral Oncology, Department of Experimental Oncology, Istituto Nazionale Tumori IRCCS Fondazione Pascale, 80131 Napoli, Italy 2Department of Microbiology and Immunology, Institute of Human Virology, Baltimore, MD 21201, USA 3Department of Research, International Prevention Research Institute, 69006 Lyon, France 4Department of Pathology, Istituto Nazionale Tumori IR...

1Unit of Molecular Biology and Viral Oncology, Department of Research, Istituto Nazionale Tumori, IRCCS, Fond. Pascale, 80131 Napoli, Italy 2Institute of Human Virology, University of Maryland Medical School, Baltimore, MD 21201, USA 3Department of Research, Institute for Advanced Biosciences, Grenoble Alpes University (UGA), 38700 La Tronche, France 4Department of Pathology, Università della C...