Introduction: To evaluate the vascular complications and their correlation with different risk factors among type-2 diabetic patients in Hyderabad, Sindh, Pakistan.
 Methodology: Cross-sectional study was conducted at department of medicine Isra University Hospital, Hyderabad from March to September 2021. Type 2 diabetics either sex, between ages 20 70 years, on medication, were included s...

Diabetes mellitus leads to long-term complications involving multiple organs and systems of the human body. Among list complications, a relatively vascular complication increases morbidity condition. Patients with diabetes are influenced by various factors like hyperglycaemic state, insulin resistance, oxidative stress, metabolic condition obesity, all mentioned conditions also present platelet...

A debilitating consequence of diabetes mellitus (DM) is neuropathy which globally affects between 20 -30% of diabetic patients and up to 50% [1, 2]. The lifetime incidence of diabetic neuropathy (DN) is estimated to be up to 45% for type 2 diabetic patients and 59% for type 1 diabetic patients in USA. The risk of DN rises with age, duration of DM, and vascular disease. Characterized by damages ...

Introduction: Air embolism is a rare and potentially fatal acute complication. Its causes are mainly iatrogenic. It requires rapid diagnostics treatment, including hyperbaric oxygen therapy (HBOT). Aim: The main aim was to present the potential of air during hemodialysis (HD) show importance quick clinical diagnosis – on base case. Case study: 65-years old male patient with diabetic nephropathy...

Hemorrhagic transformation is an important complication of acute ischemic stroke, particularly in diabetic patients receiving thrombolytic treatment with tissue plasminogen activator, the only approved drug for the treatment of acute ischemic stroke. The objective of the present study was to determine the effects of acute manipulation of potential targets for vascular protection [i.e., NF-κB, p...

Diabetic macular edema, resulting from increased microvascular permeability, is the most prevalent cause of vision loss in diabetes. The mechanisms underlying this complication remain poorly understood. In the current study, diabetic vascular permeability (blood-retinal barrier breakdown) is demonstrated to result from a leukocyte-mediated Fas-FasL-dependent apoptosis of the retinal vasculature...

BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM). Diabetic causes permanent blindness in the productive age group and has multifactorial pathogenesis. MicroRNA-126 (miRNA-126) regulates expression vascular endothelial growth factor (VEGF) gene at post-transcriptional level, VEGF being an important angiogenic protein regulating inflammation DR develop...

conclusions in conclusion, the ace and pparg genes do not have a key role in conferring risk for diabetic nephropathy. results ace id genotypes followed hardy-weinberg equilibrium in both cases and controls. but p12a genotypes deviated from hardy-weinberg equilibrium in diabetic controls. chi2 test was applied for the analysis of genotypic distributions in genotypic and dominant models. odds ra...

Methylglyoxal (MGO), an active metabolite of glucose, has been reported to induce vascular cell apoptosis in diabetic complication. Polydatin (PD), a small natural compound from Polygonum cuspidatum, has a number of biological functions, such as antioxidative, anti-inflammatory, and nephroprotective properties. However, the protective effects of PD on MGO-induced apoptosis in endothelial cells ...

Diabetic nephropathy is a major cause of endstage renal disease worldwide and is characterised by persistent albuminuria, functional and structural changes in the glomerulus. Patients with diabetes mellitus with kidney damage are at higher risk of fatal and nonfatal cardiovascular events.1 Evidence shows that nitric oxide pathway plays an important role in the development of vascular complicati...