Diabetic retinopathy, a retinal vascular disease, is inhibited in animals treated with aminoguanidine, an inhibitor of inducible nitric-oxide synthase. This treatment also reduces retinal protein nitration, which is greater in diabetic rat retina than nondiabetic retina. As an approach to understanding the molecular mechanisms of diabetic retinopathy, we sought the identity of nitrotyrosine-con...

abstract  introduction: hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. with c onsidering the potential anti-diabetic effect of the medicinal plant withania somnifera (ws)( ashwagandha), this study was designed to investigate the analgesic effect of ws on formalin-induced nociceptive responses (standard formali...

▼ Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10–20 % of patients with diabetes, or roughly 40–50 % patients with diabetic neuropathy. However, the pathogenesis of diabetic neuropathic pain is still largely unknown. Several animal models have been used to study the underlying mechanisms for this complication. Some commonly used animal models include stre...

OBJECTIVE Diabetes-induced dyslipidemia is seen in streptozotocin-induced diabetic rats. This is caused, in part, by elevated intestinal acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity. Because two ACAT isozymes (ACAT-1 and ACAT-2) were identified, in the present study we determined which ACAT isozyme was involved in the elevated intestinal ACAT activity in diabetic rats. METHODS ...

Allogeneic and autoimmune islet destruction limits the success of islet transplantation in autoimmune diabetic patients. This study was designed to investigate whether ex vivo gene transfer of viral interleukin-10 (vIL-10) protects BioBreeding (BB) rat islets from autoimmune destruction after transplantation into diabetic BB recipients. Islets were transduced with adenoviral constructs (Ad) exp...

In an earlier report (1) we compared the responses of hepatic glycolytic enzyme activities of normal rats fed either glucose or fructose for 3 days. The enzymes studied were phosphoglucomutase, glucose 6-phosphatase, phosphoglucose isomerase, and the dehydrogenases of glucose B-phosphate and gluconate g-phosphate. When the diets containing free hexoses were substituted for the stock diet, the a...

Diabetic wounds may become chronic if left untreated. In the current study, a potential wound dressing was developed by incorporating fumaria officinalis extract-loaded chitosan nanoparticles (FOE-CHNPs) into calcium alginate hydrogel. The produced hydrogel evaluated regarding its microarchitecture, cytotoxicity, cell migration activity, cytoprotective potential, porosity, in vitro anti-inflamm...

Increased generation of oxidants and (or) reduced endogenous antioxidant defense mechanisms are associated with the etiology of diabetic vascular complications. The aim of the present study was to evaluate whether curcumin supplementation increases the vasodilatory effect of cilostazol in streptozotocin induced diabetic rat aorta. Cumulative addition of cilostazol caused concentration-dependent...

patients afflicted by diabetes mellitus (dm) usually have more infections than those without dm. the course of the infections is also more complicated in this group of patients. one of the possible causes of increased infections prevalence is a deficiency in the immunity. besides some decreased cellular responses in vitro, no disturbances in adaptive immunity in diabetic patients have been desc...